ID H2N001_ORYLA Unreviewed; 359 AA.
AC H2N001;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Asporin {ECO:0000256|PIRNR:PIRNR002490};
GN Name=aspn {ECO:0000313|Ensembl:ENSORLP00000024684.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000024684.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000024684.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024684.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000024684.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024684.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR002490}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class I subfamily. {ECO:0000256|ARBA:ARBA00009811,
CC ECO:0000256|PIRNR:PIRNR002490}.
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DR RefSeq; XP_004086170.1; XM_004086122.2.
DR AlphaFoldDB; H2N001; -.
DR STRING; 8090.ENSORLP00000024684; -.
DR Ensembl; ENSORLT00000024685.2; ENSORLP00000024684.2; ENSORLG00000019874.2.
DR GeneID; 101155994; -.
DR KEGG; ola:101155994; -.
DR CTD; 54829; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157444; -.
DR HOGENOM; CLU_000288_186_0_1; -.
DR InParanoid; H2N001; -.
DR OrthoDB; 3953748at2759; -.
DR TreeFam; TF334562; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000019874; Expressed in muscle tissue and 10 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR016352; SLRP_I_decor/aspor/byglycan.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF2; ASPORIN; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01462; LRRNT; 1.
DR PIRSF; PIRSF002490; SLRP_I; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002490-1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530,
KW ECO:0000256|PIRNR:PIRNR002490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..359
FT /note="Asporin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017194748"
FT DOMAIN 52..84
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DISULFID 53..59
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT DISULFID 57..66
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT DISULFID 311..344
FT /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
SQ SEQUENCE 359 AA; 40900 MW; 118CD4667FF32654 CRC64;
MRVLLLLCLL SFGKTKPYQP VNVMDLMKNH DIMIADSDED DDEEDDDYDD EDCPANCRCS
PQVVQCSDQG LISVPEKIPE DTMMIDLQNN DITEIKEDDF KGLHKLYGLF LINNRISKVH
PNAFKNMDHL RLLYLSYNLL TEIPANLPPN VIELRFYENN INRIQKNAFD GLRKLHVLEL
GANPLANSGI EVGAFNGLST LYIGIAEAKL TSVPKDLPSS IKELSLDYNK IAKVEVEDFI
RYKNLQRLGL AFNQIKFVEN GSLIRIPNIH EIHLDHNRLK KVPPGLNSLR YLQVIFLHNN
KISYVGMNDF CPSSTGGKKN PYTGISLFAN PVKYWNIQPA IFRCVTGRRA VHLGNFRKK
//