ID H2N0P9_ORYLA Unreviewed; 459 AA.
AC H2N0P9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Interferon regulatory factor 5 {ECO:0000313|Ensembl:ENSORLP00000024965.2};
GN Name=irf5 {ECO:0000313|Ensembl:ENSORLP00000024965.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000024965.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000024965.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024965.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000024965.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000024965.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004085073.1; XM_004085025.2.
DR RefSeq; XP_011491717.1; XM_011493415.1.
DR AlphaFoldDB; H2N0P9; -.
DR Ensembl; ENSORLT00000024966.2; ENSORLP00000024965.2; ENSORLG00000020118.2.
DR GeneID; 101173363; -.
DR KEGG; ola:101173363; -.
DR CTD; 3663; -.
DR eggNOG; ENOG502QSKM; Eukaryota.
DR GeneTree; ENSGT00940000159926; -.
DR HOGENOM; CLU_083205_0_0_1; -.
DR OrthoDB; 3740806at2759; -.
DR TreeFam; TF328512; -.
DR Proteomes; UP000001038; Chromosome 23.
DR Bgee; ENSORLG00000020118; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF10; INTERFERON REGULATORY FACTOR 5; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 7..115
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
SQ SEQUENCE 459 AA; 52150 MW; 44D06F966BDA44AC CRC64;
MSVQPRRVRL KPWLLAQVNS GRYPGLQWLG PDHRLFQIPW KHATRHTPVS DEENTIFKAW
AVETGKYLEG VDEPDPAKWK ANLRCALNKS REFQLKYDGT KETPLQPYKI YEVCEHPGVT
DGAEEEEEMP NLMDLSINPP IGEPPFSEPP RLIPLDLPIA SDLQLQVEQR GFVQHTGLPN
GLNDLNSLPA TQAEPGLMEA STMEAVQNQT GSQNQQTFKY DLLSSVPLTD LDLKFQYRGT
TMGSETVSNP QGCRLYYGHL EPTPDQVDLF GPVSLQQVRF PGTSEIQNQK QRFYTDALLD
VMDRGLILEI LDQDIYAIRL CQCKVFWSGP GLPEPGPPNP IEREKRIKVF SLNDFLQGLI
LYQKGEAPNP PPFEVYFCFG EDWPDKKPKE RKLIIVQVVP VVARILTEMF SGEMSWSTDS
IRLQISNPDV KDQTVEQFKE LQRLLQSQNI QGPWTAIAP
//
