ID H2N0T8_ORYLA Unreviewed; 1072 AA.
AC H2N0T8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=C2H2-type domain-containing protein {ECO:0000259|PROSITE:PS50157};
GN Name=LOC101167278 {ECO:0000313|Ensembl:ENSORLP00000025012.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025012.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000025012.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025012.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000025012.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025012.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2N0T8; -.
DR Ensembl; ENSORLT00000025013.2; ENSORLP00000025012.2; ENSORLG00000020157.2.
DR eggNOG; KOG3623; Eukaryota.
DR GeneTree; ENSGT00950000183208; -.
DR HOGENOM; CLU_005890_0_1_1; -.
DR TreeFam; TF331759; -.
DR Proteomes; UP000001038; Chromosome 21.
DR Bgee; ENSORLG00000020157; Expressed in mesonephros and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF11; ZINC FINGER E-BOX-BINDING HOMEOBOX 2; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 103..131
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 133..160
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 174..201
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 869..896
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 897..924
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 925..953
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1072 AA; 120430 MW; 7915ACFADE89BFF1 CRC64;
ETVGQITLDN ECTGSIPIKN WVVKQWLLNC SSKPNDYFLK EEFEDSDDDS AAIVEYLQRS
DTIIIYPEAP EEAKTLRTAE ATSPKENKHG SLSDPTDDFA QLLTCPYCER GYKRLTSLKE
HIMNRHKRND ESFACQLCTG TFDSSSLLDR HMTTHKLGRE KPPPLSEEAE NRKFKCSECG
KAFKYKHHLK EHLRIHSGEK PYECSNCKKR FSHSGSYSSH ISSKKCIGLL TLNGQVHNGN
FSKSCSFPRS RTLSPESPTI PRLHPKLENG QPLFSQIQQG QPHVRGEPNY LSDYHLLMAS
QHVFEGTRVY LNGHGLSSLG IHSSPQSSLS HLGSMEVDLP LLSYTGPPVS SLSEVQKLLH
IMDNNGCRQN PEKMSQMKAY MKELEAQIQA QAGFPAVTHS SPTRSITDYT LKKVREAKSL
INKEKKQVRD KKEKSNHSGF LCSEEKSLDE QTLFLPFCCQ FCKQTFPGPI ALHQHERYLC
KMNEEIRGVL EPAENLLSGR QRTLVDELSL SNGATSPTHL LKDHFSVLNA CFAVNTEPSI
EEVGKLSHAV AGPQEFVKEW FANYESQNHQ MGSVRKKSLL PNHSAHDHHL GHSPKSLLTV
DMHCGLTNGN SSQKPEKTNH FGASRQPAGV MPHELPDILK DNTLSPLNLS NFPSHSTFSK
NSQIRSNTPS SLISEETLWD IPLDLSLPRN VKQKLVSVAE KQVRPKGLMP ECNVKLAEKE
QACVPSDLIS VKTEVLDSDI KGNFGHQPEN SASPLFGIDP FYGGSAYTPL SPHGAFTPPT
FRSSTQSTNV GLRGFSGLNP MSLLPHMAYT YTAGTTFAEM QQQKYQHKVS LPGELLDKTA
DYLSGLDNLT DSNSMLSRKK IKKTESGMYA CDLCDKTFQK TSSLLRHKYE HTGKRPHQCQ
TCKKAFKHKH HLIEHSRLHS GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY CKREADEREA
AEREAQEQGV SGLLNGGLEP SERMMGTTYL QKLEPLGSLQ PNDQEEPCNN VILRDGRETG
AGQDEKEVDS RKLMELTDRQ AASFMKKEEE EEQSLIDMTT DEEADQRDIT EK
//
