ID H2N298_ORYLA Unreviewed; 374 AA.
AC H2N298;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=glycogenin glucosyltransferase {ECO:0000256|ARBA:ARBA00038934};
DE EC=2.4.1.186 {ECO:0000256|ARBA:ARBA00038934};
GN Name=gyg2 {ECO:0000313|Ensembl:ENSORLP00000025576.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000025576.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000025576.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025576.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000025576.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000025576.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Glycogenin participates in the glycogen biosynthetic process
CC along with glycogen synthase and glycogen branching enzyme. It self-
CC glucosylates, via an inter-subunit mechanism, to form an
CC oligosaccharide primer that serves as substrate for glycogen synthase.
CC {ECO:0000256|ARBA:ARBA00043853}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-
CC glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP; Xref=Rhea:RHEA:23360,
CC Rhea:RHEA-COMP:14604, Rhea:RHEA-COMP:14605, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:46858, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:140573; EC=2.4.1.186;
CC Evidence={ECO:0000256|ARBA:ARBA00043655};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23361;
CC Evidence={ECO:0000256|ARBA:ARBA00043655};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-
CC D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+)
CC + UDP; Xref=Rhea:RHEA:56560, Rhea:RHEA-COMP:14606, Rhea:RHEA-
CC COMP:14607, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:140574; EC=2.4.1.186;
CC Evidence={ECO:0000256|ARBA:ARBA00043795};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56561;
CC Evidence={ECO:0000256|ARBA:ARBA00043795};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004964}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 8 family. Glycogenin
CC subfamily. {ECO:0000256|ARBA:ARBA00038162}.
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DR RefSeq; XP_011492779.1; XM_011494477.1.
DR AlphaFoldDB; H2N298; -.
DR STRING; 8090.ENSORLP00000025576; -.
DR Ensembl; ENSORLT00000025577.2; ENSORLP00000025576.2; ENSORLG00000020649.2.
DR GeneID; 101169587; -.
DR CTD; 8908; -.
DR eggNOG; KOG1950; Eukaryota.
DR GeneTree; ENSGT00940000161628; -.
DR HOGENOM; CLU_017171_0_0_1; -.
DR InParanoid; H2N298; -.
DR OrthoDB; 306230at2759; -.
DR TreeFam; TF312839; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000020649; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008466; F:glycogenin glucosyltransferase activity; IEA:UniProt.
DR GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02537; GT8_Glycogenin; 1.
DR InterPro; IPR002495; Glyco_trans_8.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR11183; GLYCOGENIN SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11183:SF164; GLYCOGENIN-1; 1.
DR Pfam; PF01501; Glyco_transf_8; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis {ECO:0000256|ARBA:ARBA00023056};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT REGION 249..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 42209 MW; 17B0EDA8C9AEE634 CRC64;
MPADEAFVTL VTSDSYCQGA EVVARSLRRH GTTRPVVVMV TPNVSEQRRF SLHSDFDEVV
LVDPLPSQNP SPSPWRCPEL SLTKIQCWTL TQFRKCVFLE ADTLVLSNVD ELFQREELSA
APDPAWPDCF NSGVFVFTPS LHTHSRLLQH AEQHAEQHAG VDGADQVLLN SFFSSWPLQN
LHHRLPFVYN LISSCCYSYL PAFTQFGHHA KIVHFTGALK PWSRQREAAP PDPLERFWSL
WWKEHLSRSA EGQPGRRAEN QQIPEQRAEV PVQERLDTCS SLLPHFTAPL QNLDPDPQLT
PSTEAPQPPE GAGCSERPED PPPAVEEAED GASPPGAAET QELQHRRRWE AGQADYLGRD
AFQNIQKMLD RFLD
//
