ID H2N396_PONAB Unreviewed; 431 AA.
AC H2N396; A0A2J8TDK4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=BECN2 isoform 1 {ECO:0000313|EMBL:PNJ31112.1};
DE SubName: Full=Beclin 2 {ECO:0000313|Ensembl:ENSPPYP00000000063.2};
GN Name=BECN2 {ECO:0000313|Ensembl:ENSPPYP00000000063.2};
GN ORFNames=CR201_G0035808 {ECO:0000313|EMBL:PNJ31112.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000000063.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000000063.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ31112.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ31112.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000000063.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beclin family.
CC {ECO:0000256|ARBA:ARBA00005965}.
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DR EMBL; NDHI03003506; PNJ31112.1; -; Genomic_DNA.
DR RefSeq; XP_002809296.1; XM_002809250.1.
DR STRING; 9601.ENSPPYP00000000063; -.
DR Ensembl; ENSPPYT00000000070.2; ENSPPYP00000000063.2; ENSPPYG00000000066.2.
DR GeneID; 100453615; -.
DR KEGG; pon:100453615; -.
DR CTD; 441925; -.
DR eggNOG; KOG2751; Eukaryota.
DR GeneTree; ENSGT00390000008164; -.
DR HOGENOM; CLU_024219_4_1_1; -.
DR OMA; DEGICAF; -.
DR OrthoDB; 11439at2759; -.
DR TreeFam; TF314282; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:1990172; P:G protein-coupled receptor catabolic process; IEA:Ensembl.
DR Gene3D; 6.10.250.3110; -; 1.
DR Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR InterPro; IPR007243; Atg6/Beclin.
DR InterPro; IPR038274; Atg6/Beclin_C_sf.
DR InterPro; IPR041691; Atg6/beclin_CC.
DR InterPro; IPR040455; Atg6_BARA.
DR PANTHER; PTHR12768; BECLIN 1; 1.
DR PANTHER; PTHR12768:SF5; BECLIN-2; 1.
DR Pfam; PF04111; APG6; 1.
DR Pfam; PF17675; APG6_N; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 116..242
FT /note="Atg6/beclin coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF17675"
FT DOMAIN 246..426
FT /note="Atg6 BARA"
FT /evidence="ECO:0000259|Pfam:PF04111"
FT REGION 21..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 166..249
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 52..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 48144 MW; 8BEDBF57E67AC889 CRC64;
MSSIRFLCQR CHQALKLSCS SESGSLPAAP APTSGQAEPG DTREPGATTR EVTDAGEQQD
GASSRSLPGD GSVSKDHANI FTLLGELGAM HMLGSIQKAA GDIFDIVSGQ EVVDHPLCEE
CTDSLLEHLD IQLALTEAES QNYQRCLETG ELATSEDEPA ALWAELRDLK LEEARLVQEL
EDVDRNNARA AADLEAAQAE AAELDQQERQ YYRDYSALKW QQLELLDQLG NVENQLQYAR
VQMDRLEEIN CFTATFEICV EGPLGVINNF RLGRLPTVRV GWNEINTAWG QAALLLLALA
NTIGLQFQRY RLIPCGNHSY LKSLTDDRTE LPLFCYGGQD VFLDNKYDRA MVAFLDCMQQ
FKEEAEKGEL GLCLPYRIQV GTGLMEDVGG RGECYSIRTH LNTQELWTKA LKFMLINFKW
SLIWVASRYQ K
//
