ID H2N436_PONAB Unreviewed; 376 AA.
AC H2N436; A0A2J8UXA7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Fibromodulin {ECO:0000256|ARBA:ARBA00018230};
DE AltName: Full=Keratan sulfate proteoglycan fibromodulin {ECO:0000256|ARBA:ARBA00032216};
GN Name=FMOD {ECO:0000313|Ensembl:ENSPPYP00000000367.3};
GN ORFNames=CR201_G0024051 {ECO:0000313|EMBL:PNJ49896.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000000367.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000000367.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ49896.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ49896.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000000367.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Affects the rate of fibrils formation. May have a primary
CC role in collagen fibrillogenesis. {ECO:0000256|ARBA:ARBA00025136}.
CC -!- SUBUNIT: Binds to type I and type II collagen.
CC {ECO:0000256|ARBA:ARBA00011226}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class II subfamily. {ECO:0000256|ARBA:ARBA00005818}.
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DR EMBL; NDHI03003439; PNJ49896.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000000367; -.
DR Ensembl; ENSPPYT00000000384.3; ENSPPYP00000000367.3; ENSPPYG00000000332.3.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157007; -.
DR HOGENOM; CLU_000288_186_4_1; -.
DR OMA; KLLYVRM; -.
DR OrthoDB; 521898at2759; -.
DR TreeFam; TF334562; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF4; FIBROMODULIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..376
FT /note="Fibromodulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041199277"
FT DOMAIN 75..109
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
SQ SEQUENCE 376 AA; 43154 MW; 3D041BBBA2613F66 CRC64;
MQWTSLLLLA GLFSLSQAQY DDDPHWWFHY LRSQQSTYYD PYDPYPYETY EPYPYGVDEG
PAYTYGSPSP PNPRDCPQEC DCPPNFPTAM YCDNRNLKYL PFVPSRMKYV YFQNNQITSI
QEGVFDNATG LLWIALHGNQ ITSDKVGKKV FSKLRHLERL YMDHNNLTRM PGPLPRSLRE
LHLDHNQISR VPNNALEGLE NLTALYLQHN EIQEVGSSMR GLRSLILLDL SYNHLRRVPD
GLPSALEQLY MEHNNVYTVP DSYFQGAPKL LYVRLSHNSL TNNGLASNTF NSSSLLELDL
SYNQLQKIPP VNTNLENLYL QGNRINEFSI SSFCTVVDVV NFSKLQVLRL DGNEIKRSAM
PADAPLCLRL ASLIEI
//
