ID H2N4B1_PONAB Unreviewed; 270 AA.
AC H2N4B1; A0A2J8UXY2; A0A6D2WMI3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Complement factor H related 2 {ECO:0000313|Ensembl:ENSPPYP00000000442.2};
DE SubName: Full=T0083661 isoform 1 {ECO:0000313|EMBL:PNJ50127.1};
GN Name=CFHR2 {ECO:0000313|Ensembl:ENSPPYP00000000442.2};
GN ORFNames=CR201_G0024209 {ECO:0000313|EMBL:PNJ50127.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000000442.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000000442.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ50127.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ50127.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000000442.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; NDHI03003439; PNJ50127.1; -; Genomic_DNA.
DR RefSeq; XP_009238002.1; XM_009239727.1.
DR STRING; 9601.ENSPPYP00000000442; -.
DR Ensembl; ENSPPYT00000000461.3; ENSPPYP00000000442.2; ENSPPYG00000000390.3.
DR GeneID; 103888513; -.
DR KEGG; pon:103888513; -.
DR CTD; 3080; -.
DR eggNOG; ENOG502RTVV; Eukaryota.
DR GeneTree; ENSGT00940000163634; -.
DR HOGENOM; CLU_020107_3_0_1; -.
DR OMA; GKYFYYT; -.
DR OrthoDB; 4851222at2759; -.
DR TreeFam; TF326157; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0051838; P:cytolysis by host of symbiont cells; IEA:Ensembl.
DR CDD; cd00033; CCP; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45785:SF7; COMPLEMENT FACTOR H; 1.
DR PANTHER; PTHR45785; COMPLEMENT FACTOR H-RELATED; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 4.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR PROSITE; PS50923; SUSHI; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..270
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014574567"
FT DOMAIN 85..142
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 147..205
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 149..192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 270 AA; 30669 MW; 4CD162F4F1B177DB CRC64;
MWLMVSVILI SRISSVGGEA TFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV
SPSKSFWTRI TCTEEGWSPT PKCLRLCFFP FVENGHSESS GQTHLEGDTV QIICNTGYRL
QNNENNISCV ERGWSTPPKC RSTVSAEKCG PPPPIDNGDI TSFPLSVYAP GSSVEYQCQN
LYQLEGNNQI TCRNGQWSEP PKCLHPCVIS QEIMEKYNIK LKWTNQQKLY SRTGDIVEFV
CKSAYYPTKS HSFRAVCQNG KLVYPSCEEK
//