ID H2N4H5_PONAB Unreviewed; 694 AA.
AC H2N4H5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Solute carrier family 53 member 1 {ECO:0000256|ARBA:ARBA00035271};
DE AltName: Full=Phosphate exporter SLC53A1 {ECO:0000256|ARBA:ARBA00035512};
GN Name=XPR1 {ECO:0000313|Ensembl:ENSPPYP00000000513.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000000513.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000000513.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000000513.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphate(in) = phosphate(out); Xref=Rhea:RHEA:32823,
CC ChEBI:CHEBI:43474; Evidence={ECO:0000256|ARBA:ARBA00035090};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32824;
CC Evidence={ECO:0000256|ARBA:ARBA00035090};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
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DR AlphaFoldDB; H2N4H5; -.
DR Ensembl; ENSPPYT00000000534.2; ENSPPYP00000000513.2; ENSPPYG00000000449.3.
DR eggNOG; KOG1162; Eukaryota.
DR GeneTree; ENSGT00500000044895; -.
DR HOGENOM; CLU_006116_3_0_1; -.
DR InParanoid; H2N4H5; -.
DR OMA; KKRGDNC; -.
DR TreeFam; TF314643; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IEA:Ensembl.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0001618; F:virus receptor activity; IEA:Ensembl.
DR GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:Ensembl.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR CDD; cd14477; SPX_XPR1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 3.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..175
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 437..641
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
FT COILED 68..95
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 694 AA; 81282 MW; 7BD6DD84E5A35156 CRC64;
MKFAEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSVE DEDTVKRYFA KFEEKFFQTC
EKELAKINTF YSEKLAEAQR RFATLQNELQ SSLDAQKEST GVTTLRQRRK PVFHLSHEER
VQHRNIKDLK LAFSEFYLSL ILLQNYQNLN FTGFRKILKK HDKILETSRG ADWRVAHVEV
APFYTCKKIN QLISETEAVV TNELEDGDRQ KAMKRLRVPP LGAAQPAPAW TTFRVGLFCG
IFIVLNITLV LAAVFKLETD RSIWPLIRIY RGGFLLIEFL FLLGINTYGW RQAGVNHVLI
FELNPRSNLS HQHLFEIAGF LGILWCLSLL ACFFAPISVI PTYVYPLALY GFMVFFLINP
TKTFYYKSRF WLLKLLFRVF TAPFHKVGFA DFWLADQLNS LSVILMDLEY MICFYSLELK
WDESKGLLPN NSEESGICHK YTYGVRAIVQ CIPAWLRFIQ CLRRYRDTKR AFPHLVNAGK
YSTTFFMVTF AALYSTHKER GHSDTMVFFY LWIVFYIISS CYTLIWDLKM DWGLFDKNAG
ENTFLREEIV YPQKAYYYCA IIEDVILRFA WTIQISITST TLLPHSGDII ATVFAPLEVF
RRFVWNFFRL ENEHLNNCGE FRAVRDISVA PLNADDQTLL EQMMDQDDGV RNRQKNRSWK
YNQSISLRRP CLASQSKARD TKVLIEDTDD EANT
//
