ID H2N4L3_PONAB Unreviewed; 1228 AA.
AC H2N4L3; A0A2J8UC04;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=ASTN1 isoform 1 {ECO:0000313|EMBL:PNJ42812.1};
DE SubName: Full=Astrotactin 1 {ECO:0000313|Ensembl:ENSPPYP00000000551.2};
GN Name=ASTN1 {ECO:0000313|Ensembl:ENSPPYP00000000551.2};
GN ORFNames=CR201_G0028998 {ECO:0000313|EMBL:PNJ42812.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000000551.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000000551.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ42812.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ42812.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000000551.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003464; PNJ42812.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000000573.2; ENSPPYP00000000551.2; ENSPPYG00000000478.3.
DR eggNOG; ENOG502R4QT; Eukaryota.
DR GeneTree; ENSGT00390000003140; -.
DR TreeFam; TF332034; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0001764; P:neuron migration; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR040685; Annexin-like.
DR InterPro; IPR045574; ASTN1_2_Fn3.
DR InterPro; IPR045575; ASTN_1_2_N.
DR InterPro; IPR026995; Astrotactin.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR16592; -; 1.
DR PANTHER; PTHR16592:SF8; ASTROTACTIN-1; 1.
DR Pfam; PF18411; Annexin_2; 1.
DR Pfam; PF19743; ASTN1_2_fn3; 1.
DR Pfam; PF19441; ASTN_1_2_N; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1228
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041158232"
FT TRANSMEM 151..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..499
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 603..644
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 651..700
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 803..991
FT /note="MACPF"
FT /evidence="ECO:0000259|SMART:SM00457"
FT REGION 340..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 136529 MW; 876D98328156B2F5 CRC64;
MALAGLCALL ACCWGPAAVL ATAAGDVDPS KELECKLKSI TVSALPFLRE NDLSIMHSPS
ASEPKLLFSV RNDFPGEMVV VDDLENTELP YFVLEISGNT EDIPLVRWRQ QWLENGTLLF
HIHHQDGAPS LPGQDPTEEP QHESAEEELR ILHISVMGGM IALLLSILCL VMILYTRRRW
CKRRRVPQPQ KSASAEAANE IHYIPSVLIG GHGRESLRNA RVQGHNSSGT LSIRETPILD
GYEYDITDLR HHLQRECMNG GEDFASQVTR TLDSLQGCNE KSGMDLTPGS DNAKLSLMNK
YKDNIIATSP VDSNHQQATL LSHTSSSQRK RINNKARAGS AFLNPEGDSG TEAENDPQLT
FYTDPSRSRR RSRVGSPRSP VNKTTLTLIS ITSCVIGLVC SSHVNCPLVV KITLHVPEHL
IADGSRFILL EGSQLDASDW LNPAQVVLFS QQNSSGPWAM DLCARRLLDP CEHQCDPETG
ECLCYEGYMK DPVHKHLCIR NEWGTNQGPW PYTIFQRGFD LVLGEQPSDK IFRFTYTLGE
GMWLPLSKSF VIPPAELAIN PSAKCKTDMT VMEDAVEVRE ELMTSSSFDS LEVLLDSFGP
VRDCSKDNGG CSKNFRCISD RKLDSTGCVC PSGLSPMKDS SGCYDRHIGV DCSDGFNGGC
EQLCLQQMAP FPDDPTLYNI LMFCGCIEDY KLGVDGRSCQ LITEICPEGS DCGESRELPM
NQTLFGEMFF GYNNHSKEVA AGQVLKGTFR QNNFARGLDQ QLPDGLVVAT VPLENQCLEE
ISEPTPDPDF LTGMVNFSEV SGYPVLQHWK VRSVMYHIKL NQVAISQALS NALHSLDGAT
SRADFVALLD HFGNHYIQEA IYGFEESCSI WYPNKQVQRR LWLEYEDISK GNSPSDESEE
RERDPKVLTF PEYIASLSDS GTKRMVAGVR MECQSKGRCP SSCPLCHVTT SPDTPAEPVL
LEVTKAAPIY ELVTNNQTQR LLQEATMSSL WCSGTGDVIE DWCRCDSTAF GADGLPTCAP
LPQPVLRLST VHEPSSTLVV LEWEHSEPPI GVQIVDYLLR QEKVTDRMDH SKVETETVLS
FVDDIISGAK SPCAMPSQVP DKQLTTISLI IRCLEPDTIY MFTLWGVDNT GRRSRPSDVI
VKTPCPVVDD VKAQEIADKI YNLFNGYTSG KEQQTAYNTL LDLGSPTLHR VLYHYNQHYE
SFGEFTWRCE DELGPRLPAC WDSQRSCR
//
