ID H2N4V5_PONAB Unreviewed; 164 AA.
AC H2N4V5; A0A2J8SAN6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=T-cell surface glycoprotein CD3 zeta chain {ECO:0000256|ARBA:ARBA00020448};
DE AltName: Full=T-cell receptor T3 zeta chain {ECO:0000256|ARBA:ARBA00030941};
GN Name=CD247 {ECO:0000313|Ensembl:ENSPPYP00000000644.3};
GN ORFNames=CR201_G0044567 {ECO:0000313|EMBL:PNJ17844.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000000644.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000000644.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ17844.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ17844.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000000644.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the CD3Z/FCER1G family.
CC {ECO:0000256|ARBA:ARBA00007280}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NDHI03003587; PNJ17844.1; -; Genomic_DNA.
DR RefSeq; XP_002809881.1; XM_002809835.3.
DR Ensembl; ENSPPYT00000000669.3; ENSPPYP00000000644.3; ENSPPYG00000000551.3.
DR KEGG; pon:100458470; -.
DR eggNOG; ENOG502S5AZ; Eukaryota.
DR GeneTree; ENSGT00390000018208; -.
DR HOGENOM; CLU_119104_0_0_1; -.
DR OMA; EMGGKQP; -.
DR OrthoDB; 5313660at2759; -.
DR TreeFam; TF330937; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0042105; C:alpha-beta T cell receptor complex; IEA:Ensembl.
DR GO; GO:0033001; C:Fc-gamma receptor III complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IEA:Ensembl.
DR GO; GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR InterPro; IPR021663; CD3_zeta/IgE_Fc_rcpt_gamma.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR InterPro; IPR024128; T-cell_CD3_zeta.
DR PANTHER; PTHR10035; T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; 1.
DR PANTHER; PTHR10035:SF2; T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN; 1.
DR Pfam; PF02189; ITAM; 2.
DR Pfam; PF11628; TCR_zetazeta; 1.
DR SMART; SM00077; ITAM; 3.
DR PROSITE; PS51055; ITAM_1; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..164
FT /note="T-cell surface glycoprotein CD3 zeta chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041158234"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 83..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 164 AA; 18664 MW; CFC9AF01487483AF CRC64;
MKWKAIVTAA ILQAQFPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRLKFSRSAD
PPAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNALQKDKMA
EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR
//
