ID H2N767_PONAB Unreviewed; 2109 AA.
AC H2N767; A0A2J8S3A6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=DOCK7 isoform 6 {ECO:0000313|EMBL:PNJ15261.1};
DE SubName: Full=Dedicator of cytokinesis 7 {ECO:0000313|Ensembl:ENSPPYP00000001493.3};
GN Name=DOCK7 {ECO:0000313|Ensembl:ENSPPYP00000001493.3};
GN ORFNames=CR201_G0046619 {ECO:0000313|EMBL:PNJ15261.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000001493.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000001493.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ15261.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ15261.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000001493.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; NDHI03003616; PNJ15261.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000001493; -.
DR Ensembl; ENSPPYT00000001540.3; ENSPPYP00000001493.3; ENSPPYG00000001280.3.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000155661; -.
DR HOGENOM; CLU_000624_0_0_1; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11703; DHR2_DOCK7; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF78; DEDICATOR OF CYTOKINESIS PROTEIN 7; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 561..727
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1647..2083
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 138..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2109 AA; 239442 MW; 97230BE67E028297 CRC64;
MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNLV GNISHHTTVP LTEAVDPVDL
EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY
TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS
MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP
SPDEEEPIER LSVPDVPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF
YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE
PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST
EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL
SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR
PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP
VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN
TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF
NVEVVAVSSI HTQDPYLDKF FALVNALDEH MFPVRIGDMR IMENNLENEL KSSISALNSS
QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG
RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS
NPDISGTPTS PDDEVRSIIG SKAMDRSCNR MSSHTETSSF LQTLTGRLPT KKLFHEELAL
QWVVCSGSVR ESALQQAWFF FELMVKSMVH HLYFNDKLDA PRKSRFPERF MDDIAALVST
IASDIVSRFQ KDTEMVERLN TSLAFFLNDL LSVMDRGFVF SLIKSCYKQV SSKLYSLPNP
SVLVSLRLDF LRIICSHEHY VTLNLPCSLL TPPASPSPSV SSATSQSSGF STNVQDQKIA
NMFELSVPFR QQHYLAGLVL TELAVILDPD AEGLFGLHKK VINMVHNLLS SHDSDPRYSD
PQIKARVAML YLPLIGIIME TVPQLYDFTE THNQRGRPIC IATDDYESES GSMISQTVAM
AIAGTSVPQL TRPGSFLLTS TSGRQHTTFS AESSRSLLIC LLWVLKNADE TVLQKWFTDL
SVLQLNRLLD LLYLCVSCFE YKGKKVFERM NSLTFKKSKD MRAKLEEAIL GSIGARQEMV
RRSRGQLGTY TIASPPERSP SGSAFGSQEN LRWRKDMTHW RQNTEKLDKS RAEIEHEALI
DGNLATEANL IILDTLEIVV QTVSVTESKE SILGGVLKVL LHSMACNQSA VYLQHCFATQ
RALVSKFPEL LFEEETEQCA DLCLRLLRHC SSSISTIRSH ASASLYLLMR QNFEIGNNFA
RVKMQVTMSL SSLVGTSQNF NEEFLRRSLK TILTYAEEDL ELRETTFPDQ VQDLVFNLHM
ILSDTVKMKE HQEDPEMLID LMYRIAKGYQ TSPDLRLTWL QNMAGKHSER SNHAEAAQCL
VHSAALVAEY LSMLEDRKYL PVGCVTFQNI SSNVLEESAV SDDVVSPDEE GICSGKYFTE
SGLVGLLEQA AASFSMAGMY EAVNEVYKVL IPIHEANRDA KKLSTIHGKL QEAFSKIVHQ
STGWERMFGT YFRVGFYGTK FGDLDEQEFV YKEPAITKLA EISHRLEGFY GERFGEDVVE
VIKDSNPVDK CKLDPNKAYI QITYVEPYFD TYEMKDRITY FDKNYNLRRF MYCTPFTLDG
RAHGELHEQF KRKTILTTSH AFPYIKTRVN VTHKEEIILT PIEVAIEDMQ KKTQELAFAT
HQDPADPKML QMVLQGSVGT TVNQGPLEVA QVFLSEIPSD PKLFRHHNKL RLCFKDFTKR
CEDALRKNKS LIGPDQKEYQ RELERNYHRL KEALQPLINR KIPQLYKAVL PVTCHRDSFS
RMSLRKMDL
//
