ID H2N7Y9_PONAB Unreviewed; 863 AA.
AC H2N7Y9; A0A2J8Y6N2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=CSF3R isoform 1 {ECO:0000313|EMBL:PNJ89926.1};
DE SubName: Full=Colony stimulating factor 3 receptor {ECO:0000313|Ensembl:ENSPPYP00000001772.3};
GN Name=CSF3R {ECO:0000313|Ensembl:ENSPPYP00000001772.3};
GN ORFNames=CR201_G0015666 {ECO:0000313|EMBL:PNJ89926.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000001772.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000001772.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ89926.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ89926.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000001772.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; NDHI03003278; PNJ89926.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000001829.3; ENSPPYP00000001772.3; ENSPPYG00000001536.3.
DR eggNOG; ENOG502QT3H; Eukaryota.
DR GeneTree; ENSGT00940000158915; -.
DR HOGENOM; CLU_017990_0_0_1; -.
DR OMA; SYCSIPR; -.
DR TreeFam; TF338122; -.
DR Proteomes; UP000001595; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR GO; GO:0051916; F:granulocyte colony-stimulating factor binding; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0045637; P:regulation of myeloid cell differentiation; IEA:Ensembl.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF103; GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..863
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117533"
FT TRANSMEM 626..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 233..332
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 334..430
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 431..528
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 530..623
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 863 AA; 95067 MW; 8B562B9957912289 CRC64;
MARLGTCSLT WAALIILLLP GSLEECGHIS VSAPIVHLGD PITASCIIKQ NCSHLDPEPQ
ILWRLGAELQ PGGRQQRLSD GTQESIITLP HLNYTQAFLS CCLNWGNSLQ ILDQVELRAG
YPPAVPHNLS CLMNLTTSSL ICQWEPGPET HLPTSFTLKS FKSRGNCQTQ GDSILDCVPK
DGQSHCSIPR RHLLLYQNMG IWVQAENALG TSMSPQLCLD PMDVVKLEPP MLRTMDPSPE
AAPPQAGCLQ LCWEPWQPGL HINQKCELRH KPQHGEASWA LVGPLPLEAL RYELCGLLPA
TAYTLQIRCI RWPLPGHWSD WSPSLELRTT ERAPTVRLDT WWRQRQLDPR TVQLFWKPVP
LEEDSGQIQG YVVSWRPSGQ AGAILPLCNT TELSCTFHLP SEAQEVALVA YNSAGTSRPT
PVVFSESRGP ALTRLHAMAR DPHSLWVGWE PPSPWPQGYV IEWGLGPPSA SNSNKTWRME
QNGSATGFLL KENIRPFQLY EITVTPLYQD TMGPSQHVYA YSQEMAPSHA PELHLKHIGK
TWVQLEWVPE PPELGKSPLT HYTIFWTNVQ NQSFSAILNA SSRGFVLHGL EPASLYHIHL
MAASQAGATN STVLTLMTLT PEGSELHILL GLFGLLLLLT CLCGTAWLCC SPNRKNPLWP
SVPDPAHSSL GSWVPTIMEE LPGPRQGWWL GQTSEKSRAL TPHPCVQDAF QLPGLGTPPI
TKLTVLEEDK KKPVPWESHN SSETCGLPTL VQTYVLQGDP RAASTQPQSQ SGTSDQVLYG
QLLGSPTSPG PGHYLRCDST QPLLAGLTPS PKSYENLWFQ ASPLGTLVTP APSQEDDCVF
GPLLDFPLLQ GIRVHGMEGL GSF
//
