GenomeNet

Database: UniProt
Entry: H2N827_PONAB
LinkDB: H2N827_PONAB
Original site: H2N827_PONAB 
ID   H2N827_PONAB            Unreviewed;      3561 AA.
AC   H2N827;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   SubName: Full=CUB and Sushi multiple domains 2 {ECO:0000313|Ensembl:ENSPPYP00000001812};
GN   Name=CSMD2 {ECO:0000313|Ensembl:ENSPPYP00000001812};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000001812, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000001812, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000001812}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01137404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01137413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000001812; -.
DR   Ensembl; ENSPPYT00000001870; ENSPPYP00000001812; ENSPPYG00000001570.
DR   eggNOG; KOG4297; Eukaryota.
DR   eggNOG; ENOG410XPJ1; LUCA.
DR   GeneTree; ENSGT00940000159768; -.
DR   InParanoid; H2N827; -.
DR   TreeFam; TF316872; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00033; CCP; 28.
DR   CDD; cd00041; CUB; 13.
DR   Gene3D; 2.60.120.290; -; 14.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00431; CUB; 13.
DR   Pfam; PF00084; Sushi; 27.
DR   SMART; SM00032; CCP; 28.
DR   SMART; SM00042; CUB; 13.
DR   SUPFAM; SSF49854; SSF49854; 14.
DR   SUPFAM; SSF57535; SSF57535; 28.
DR   PROSITE; PS01180; CUB; 13.
DR   PROSITE; PS50923; SUSHI; 28.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3485   3506       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       66    174       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      177    238       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      311    372       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      375    486       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      489    546       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      548    656       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      659    720       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      722    830       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      835    892       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      894   1004       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1007   1066       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1068   1176       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1179   1239       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1241   1350       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1353   1413       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1415   1523       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1526   1587       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1589   1697       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1703   1764       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1766   1874       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     1877   1936       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     1938   2046       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2049   2108       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2110   2221       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2220   2281       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2283   2394       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN     2394   2456       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2457   2518       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2519   2583       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2584   2641       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2667   2724       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2725   2782       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2783   2845       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2846   2903       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2907   2964       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     2965   3023       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3024   3083       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3084   3141       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3142   3199       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3203   3261       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN     3262   3321       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DISULFID    517    544       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    863    890       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   1241   1268       {ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID   2612   2639       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2695   2722       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2753   2780       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2816   2843       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2874   2901       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2935   2962       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   2994   3021       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   3112   3139       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   3170   3197       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID   3232   3259       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   3561 AA;  387616 MW;  8FCD78657F65DB14 CRC64;
     MPRSRGRELG RCGCPAGRAR GETGISALLL DAGSRWGRPP PPTPPPLLLL MGWGLLSVSG
     AAGQNCTFQL HGPNGTVESP GFPYGYPNYA NCTWTITAEE QHRIQLVFQS FALEEDFDVL
     SVFDGPPQPE NLRTRLTGFQ LPATIVSAAT ALSLRLISDY AVSAQGFHAT YEVLPSHTCG
     NPGRLPNGIQ QGSTFNLGDK VRYSCNPGFF LEGHAVLTCH AGSENSATWD FPLPSCRFTG
     ASLPAPVISS KNWLRLHFTS DGNHRQRGFS AQYQVKKQIE LKSRGVKLMP SKDSSQKTSV
     LTQVGVSQGH NMCPDPGIPE RGKRLGSDFR LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF
     AAWSDHRPVC RARMCDAHLR GPSGIITSPN FPIQYDNNAH CVWIITALNP AKVIKLAFEE
     FDLERGYDTL TVGDGGQDGD QKTVLYILTG TSVPDLIVST NHQMWLLFQT DGSGSSLGFK
     ASYEEIEQGS CGDPGVPAYG WREGSRFRHG DTLKFECQPA FELVGQKAIT CQKNNQWSAK
     KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN HLHCVWLILA RPESRIHLAF NDIDVEPQFD
     FLVIKDGATA EAPVLGTFSG NQLPSSITSS GHVARLEFQT DHSTGKRGFN ITFTTFRHNE
     CPDPGVPVNG KRFGDSLQLG SSISFLCDEG FLGTQGSETI TCVLKEGSVV WNSAVLRCEA
     PCGGHLTSPS STILSPGWPG FYKDALSCAW VIEAQPGYPI KITFDRFKTE VNYDTLEVRD
     GRTYSAPLIG VYHGTQVPQF LISTSNYLYL LFSTDKSHSD IGFQLRYETI TLQSDHCLDP
     GIPVNGQRHG NDFYVGALVT FSCDSGYTLS DGEPLECEPN FQWSRALPSC EALCGGFIQG
     SSGTILSPGF PDFYPNNLNC TWIIETSHGK GVFFTFHTFH LESGHDYLLI TENGSFTQPL
     RQLTGSRLPA PISAGLYGNF TAQVRFISDF SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR
     KGLQFGVGDT LTFSCFPGYR LEGTARITCL GGRRRLWSSP LPRCVAECGN SVTGTQGTLL
     SPNFPVNYNN NHECIYSIQT QPGKGIQLKA RAFELSEGDV LKVYDGNNNS ARLLGVFSHS
     EMMGVTLNST SSSLWLDFIT DAENTSKGFE LQFSSFELIK CEDPGIPQFG YKVHDEGHFA
     GSSVSFSCDP GYSLRGSEEL LCLSGERRTW DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA
     PYEHNLNCIW TIEAEAGCTI GLHFLVFDTE EVHDVLRIWD GPVESGVLLK ELSGPALPKD
     LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS TAMSCNDPGI PQNGSRSGDS WEAGDSTVFQ
     CDPGYALQGS AEISCVKIEN RFFWQPSPPT CIAPCGGDLT GPSGVILSPN YPEPYPPGKE
     CDWKVTVSPD YVIALVFNIF NLEPGYDFLH IYDGRDSLSP LIGSFYGSQL PGRIESSSNS
     LFLAFRSDAS VSNAGFVIDY TENPRESCFD PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV
     EGTSTLSCIL GPDGKPVWNN PRPVCTAPCG GQYVGSDGVV LSPNYPQNYT SGQICLYFVT
     VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ HSRLLSSLSG SHTGESLPLA TSNQVLIKFS
     AKGLTPARGF HFVYQAVPRT SATQCSSVPE PRYGKRLGSD FSVGAIVRFE CNSGYALQGS
     PEIECLPVPG ALAQWNVSAP TCVVPCGGNL TERRGTILSP GFPEPYLNSL NCVWKIVVPE
     GAGIQIQVIS FVTEQNWDSL EVFDGADNTV TMLGSFSGTT VPALLNSTSN QLYLHFYSDI
     SVSAAGFHLE YKTVGLSSCP EPAVPSNGVK TGERYLVNDV VSFQCEPGYA LQGHAHISCM
     PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL SPGFPGNYPS NMDCSWKIAL PVGFGAHIQF
     LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG SELPSSLLST SHETTVYFHS DHSQNRPGFK
     LEYQAYELQE CPDPEPFANG IVRGAGYNVG QSVTFECLPG YQLTGHPVLT CQHGTNRNWD
     HPLPKCEVPC GGNITSSNGT VYSPGFPSPY SSSQDCVWLI TVPIGHGIRL NLSLLQTEPS
     GDFITIWDGP QQTAPRLGVF TRSMAKKTVH SSSNQVLLKF HRDAATGGIF AIAFSAYPLT
     KCPPPTILPN AEVVTENEEF NIGDIVRYRC LPGFTLVGNE ILTCKLGTYL QFEGPPPICE
     VHCPTNELLT DSTGVILSQS YPGSYPQFQT CSWLVRVEPD YNISLTVEYF LSEKQYDEFE
     IFDGPSGQSP LLKALSGNYS APLIVTSSSN SVYLRWSSDH AYNRKGFKIR YSAPYCSLPR
     APLHGFILGQ TSTQPGGSIH FGCNAGYRLV GHSMAICTRH PQGYHLWSEA IPLCQALSCG
     LPEAPKNGMV FGKEYTVGTK AMYSCSEGYH LQAGTEATAE CLDTGLWSNH NVPPQCVPVT
     CPDVSSISVE HGRWRLIFET QYQFQAQLML ICDPGYYYTG QRVIRCQANG KWSLGDSTPT
     CQIISCGELP IPPSGHRIGT LSVYGATAIF SCNSGYTLVG SRVRECMANG LWSGSEVRCL
     ATQTKLHSIF YKLLFDVLSS PSLTKAGHCG TPEPIVNGHI NGENYSYRGS VVYQCNAGFR
     LIGMSVRICQ QDHHWSGKTP FCVPITCGHP GNPVNGLTQG NQFNLNDVVK FVCNPGYMAE
     GAARSQCLAS GQWSDMLPTC RIINCTDPGH QENSVRQVHA SGLHRFSFGT TVSYRCNHGF
     YLLGTPVLSC QGDGTWDRPR PQCLLVSCGH PGSPPHSQMS GDSYTVGSVV RYSCIGKRTL
     VGNSTRMCGL DGHWTGSLPH CSGTSVGVCG DPGIPAHGIR LGDSFDPGSV MRFSCEAGHV
     LRGSSERTCQ ANGSWSGSQP ECGVISCGNP GTPSNARVVF SDGLVFSSSI VYECREGYYA
     TGLLSRHCSV NGTWTGSDPE CLVINCGDPG IPANGLRLGN DFRYNKTVTY QCVPGYMMES
     HRVSLLSCTK DRTWNGTKPV CKALMCKPPP LIPNGKVVGS DFMWGSSVTY ACLEGYQLSL
     PAVLTCEGNG SWTGELPQCF PVFCGDPGVP PRGRREDRGF SYRSSVSFSC HPPLVLVGSP
     RRFCQSDGTW SGTQPSCIDP TLTTCADPGV PQFGIQNNSQ GYQVGSTVLF RCQKGYLLQG
     STTRTCLPNL TWSGTPPDCV PHHCRQPETP THANVGALDL PSMGYTLIYS CQEGFSLKGG
     SEHRTCKADG SWTGKPPICL EVRPSGRPIN TAREPPLTQA LIPGDVFAKN SLWKGAYEYQ
     GKKQPAMLRV TGFQVANSKV NATMIDHSGV ELHLAGTYKK EDFHLLLQVY QITGPVEIFV
     NKFKDDHWAL DGHVSSESSG GTFIYQGSVK GQGFGQFGFQ RLDLRLLESD PESIGRHFAS
     NSSSVAAAIL VPFIALIIAG FVLYLYKHRR RPKVPFNGYA GHENTNVRAT FENPMYDRNI
     QPTDIMASEA EFTVSTVCTA V
//
DBGET integrated database retrieval system