ID H2NAB5_PONAB Unreviewed; 3184 AA.
AC H2NAB5; A0A2J8RSZ3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=WDFY family member 4 {ECO:0000313|Ensembl:ENSPPYP00000002625.2};
DE SubName: Full=WDFY4 isoform 2 {ECO:0000313|EMBL:PNJ11647.1};
GN Name=WDFY4 {ECO:0000313|Ensembl:ENSPPYP00000002625.2};
GN ORFNames=CR201_G0048751 {ECO:0000313|EMBL:PNJ11647.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000002625.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000002625.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ11647.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ11647.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000002625.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NDHI03003654; PNJ11647.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000002625; -.
DR Ensembl; ENSPPYT00000002708.2; ENSPPYP00000002625.2; ENSPPYG00000002249.2.
DR eggNOG; KOG1786; Eukaryota.
DR eggNOG; KOG1788; Eukaryota.
DR GeneTree; ENSGT00940000155684; -.
DR HOGENOM; CLU_000175_6_0_1; -.
DR OMA; PREGARN; -.
DR OrthoDB; 47483at2759; -.
DR TreeFam; TF313658; -.
DR Proteomes; UP000001595; Chromosome 10.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0036037; P:CD8-positive, alpha-beta T cell activation; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF3; WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2385..2510
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2527..2821
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2978..3019
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3084..3109
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1837..1869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2309..2346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3107..3128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1837..1852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2309..2328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3184 AA; 353618 MW; 837A213E0C7F5B7A CRC64;
MEAEDLSKAE DRNEDPGSKN EGQLAVVQPD VPHGGQSPSP TALWDMLERK FLEYQQLTHK
SPIEHQKSLL SLLPLFLKAW EHSVGIICFP SLQRLAEDVS DQLAQQLQQA LVGKPAEQAR
LAAGQLLWWK GDMDQDGYLL LKSAYVLTGT DSETLGRVAE SGLPALLLQC LYLFFVFPLD
KDELFESDLQ VQKMFVQMLL NICSDSQGLE GLLSGSELQS LLIATTCLRE HSCCFWKEPT
FCVLRAISKA QNLSIIQYLQ ATDCVRLSLQ NLSRLTDTLP APEVSEAVSL ILGFVKDSYP
VSSALFLEFE SSEGYPLLLK VLLRYDGLTQ NEVDPQLEEL LGLVVWLTTC GRSELKVFDS
VTYPQLEGFK FHHEASGVTV KNLQAFQVLQ NVFHKASDSV LCIQVLSAIR TMWAWNARNF
FLLEWTLQPI SQFVEIMPLK PAPVQEHFFQ LLEALVFELH YVPHEILRKV QHLIKESPGP
SCTLMALKSI LSIAGGDPLF TDIFRDSGLL GLLLAQLRKQ AKIMRKSGNK VSTPGVQDPE
RELTCVMLRT VVTLLKGSVR NAVVLKDHGM VPFIKIFLDD ECYREASLSI LEQLSAINAE
EYMSIIVGAL CSSTQGELQL KLDLLKSLLR ILETPKGRAA FRVSSGFNGL LSLLSDLEGS
LQEPLLQAWG SVSPRQTLEL VLYTLCAVSA ALHWDPVNGD FFRRNGLFEK MAEDLCLLGC
FGALEEEGTL LRSWADTKAR PFVDLLGTAF SSSGSLPPRI QSCLQILGFL DSMASGTLHL
RGDLKESLRA KQGPVVDAQK GEAGSDPQRN FKLWPDLEER MDEGDAAIMH PGVVCIMVRL
LPRLYHEDHP QLSEEIQCSL ASHIQSLVKS EKNRQVMCEA GMLGTLMASC HRALATSGSP
LHSRLIRIFE KLASQAIEPD VLRQFLGLGI PSPLSATTKI PDSSHAHRGN PGCSGSQTAQ
GSAEGPWPAA PDAGLHPGIT QAPQPLGESQ DSTTALQTAL SLISMTSPRN LQPQRAALAP
SFVEFDMSVE GYGCLFIPTL STVMGTSTEY SVSGGIGTGA TRPFPPPGGL TFSCWFLISR
HGAATEGHPL RFLTLVRHLA RTEQPFVCFS VSLCPDDLSL VVSTEEKEFQ PLDVMEPEDD
SEPSAGCQLQ VRCGQLLACG QWHHLAVVVT KEMKRHCTVS TCLDGQVIGS AKMLYIQSLP
GPFLSMDPSA FVDVYGYIAT PRVWKQKSSL IWRLGPTYLF EESISMETLE VINKLGPRYC
GNFQAVHVQG EDPDSEATPL IAEERVSFGL HIASSSITSV ADIRNAYNEV DSRLIAKEMN
ISSRDNAMPV FLLRNCAGHL SGSLRTIGAV AVGQLGVRIF HSSPAASSLD FIGGPAILLG
LISLATDDHT MYAAVKVLHS VLTSNAMCDF LMQHICGYQI MAFLLRKKAS LLNHRIFQLI
LSVAGTVELG FRSSAITNTG VFQHILCNFE LWMNTADNLE LSLFSHLLEI LQSPREGPRN
AEAAHQAQLI PKLIFLFNEP SLIPSKIPTI IGILACQLRG HFSTQDLLRI GLFVVYTLKP
SSVNERQICM DGALDPSLPA GSQTSGKTIW LRNQLLEMLL SVISSPQLHL SSESKEEMFL
KLGPDWFLLL LQGHLHASTT VLALKLLLHF LASPSLRTRF RDGLCAGSWV ERSTEGVDIV
MDNLKSQSPL PEQSPCLLPG FRVLNDFLAH HVHIPEVYLI VSTFFLQTPL TELTDGPKDS
LDAMLQWLLQ RHRQEEVLQA GLCTEGALLL LEMLKAIMSQ PLAGSEDGAW AQTFLASVLQ
FLSLVHRTYP QDTAWRAPEF LQTLAIAAFP LGAQKGAGAE STQNTSSPEA AAEGDSTVEG
LQAPTKAHPA RRQLREFMQL LLRELLLGAP SPKQCLPLEV LLEASPDHAT SQQKRDFQSE
VLLSAMEIFH MTSGGDAAMF RDGKEPQPSA EAAAAPSLAN ISCFTQKLVE KLYSGMFSAD
PRHILLFILE HIMVVIETAS SQRDTVLSTL YSSLNKVILY CLSKPQQSLS ECLSLLSILG
FLQEHWDVVF ATYNSNVSFL LCLMHCLLLL NERSYPEGFG LEPRPRLSTY HQVFLSPNED
VKEKREDLPS LSDVQHNIQK TVQTLWQQLV AQRQQTLEDA FKIDLSVKPG EREVKIEEVT
PLWEETMLKA WQHYLASEKK SLASRSNVAH HSKVTLWSGS LSSAMKLMPG RQAKDPECKT
EDFVSCIENY RRRGQELYAS LYKDHVQRRK CDNIKAANAW ARIQEQLFGE LGLWSQGEET
KPCSPWELDW REGPARMRKR IKRLSPLEAL SSGRHKESQD KNDHISQTNA ENQDELTPRE
AEGEPDEVGV DCTQLTFFPA LHESLHSEDF LELCRERQVI LQELLDKEKV TQKFSLVIVQ
GHLVSEGVLL FGHQHFYICE NFTLSPTGDV YCTRHCLSNI SDPFIFNLCS KDRSTDHYSC
QCHSYTDMRE LRQARFLLQE IALEIFFHNG YSKFLVFYNN DRSKAFKSFC SFQPSLKGKA
ASEDPLNLRR YPGSDRTMLQ KWQKRDISNF EYLMYLNTAA GRTYNDYMQY PVFPWVLADY
TSETLNLANP KTFRDLSKPM GAQTKERKLK FIQRFKEVEK TEGDMTVQCH YYTHYSSAII
VASYLVRMPP FTQAFCALQG GSFDVADRMF HSVKSTWESA SRENMSDVRE LTPEFFYLPE
FLTNCNGVEF GCMQDGTVLG DVQLPPWADG DPRKFISLHR QALESDFVSA NLQHWIDLIF
GYKQQGPAAV DAVNIFHPYF YGDRMNLSSI TDPLIKSTIL GFVSNFGQVP KQLFTKPHPA
RTAAGKPLPG KDVSTPMSLP GHPQPFFYSL QSLRPSQVTV KDMYLFSLGS ESPRGAIGHI
VPTEKTILAV ERNKVLLPPL WNRTFSWGFD DFSCCLGSYG SDKILMTFEN LAAWGRCLCA
VCPSPTMIVT CGTSTVVCVW ELSMTKGRPR GLRLRQALYG HTQAVTCLAA SVTFSLLVSG
SQDCTCILWD LDHLTHVTRL PTHREGISAI AISDVSGTIV SCAGAHLSLW NVNGQPLASI
TTAWGPEGAI TCCCLMEGPA WDTSQIIITG SQDGMVRVWK TEDVKMSVPG RPAGEEPPAQ
PPSPRGHKWE KNLALSRELD VSTALTGKPS KTSPAVTALA VSRNQTKLLV GDERGRIFCW
SADG
//
