ID H2NAV8_PONAB Unreviewed; 266 AA.
AC H2NAV8; A0A2J8WQU7; A0A6D2WDD7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=DKK1 isoform 1 {ECO:0000313|EMBL:PNJ72115.1};
DE SubName: Full=Dickkopf WNT signaling pathway inhibitor 1 {ECO:0000313|Ensembl:ENSPPYP00000002828.2};
DE SubName: Full=Dickkopf-like protein 1 {ECO:0000313|EMBL:AFI61653.1};
GN Name=DKK1 {ECO:0000313|EMBL:AFI61653.1,
GN ECO:0000313|Ensembl:ENSPPYP00000002828.2};
GN ORFNames=CR201_G0008318 {ECO:0000313|EMBL:PNJ72115.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000002828.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000002828.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFI61653.1}
RP NUCLEOTIDE SEQUENCE.
RA Hu L., Jiang G., Yang J., Liu S.;
RT "Molecular cloning and bioinformatic analysis of DKK1.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PNJ72115.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ72115.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSPPYP00000002828.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the dickkopf family.
CC {ECO:0000256|ARBA:ARBA00010842}.
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DR EMBL; JN966750; AFI61653.1; -; mRNA.
DR EMBL; NDHI03003381; PNJ72115.1; -; Genomic_DNA.
DR RefSeq; NP_001247409.1; NM_001260480.1.
DR STRING; 9601.ENSPPYP00000002828; -.
DR Ensembl; ENSPPYT00000002928.3; ENSPPYP00000002828.2; ENSPPYG00000002438.3.
DR GeneID; 100435550; -.
DR KEGG; pon:100435550; -.
DR CTD; 22943; -.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000161319; -.
DR HOGENOM; CLU_080459_0_0_1; -.
DR OMA; LDNYQPY; -.
DR OrthoDB; 4329885at2759; -.
DR TreeFam; TF330916; -.
DR Proteomes; UP000001595; Chromosome 10.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl.
DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR GO; GO:0048019; F:receptor antagonist activity; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:2000726; P:negative regulation of cardiac muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0042662; P:negative regulation of mesodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1904723; P:negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0042663; P:regulation of endodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0002090; P:regulation of receptor internalization; IEA:Ensembl.
DR CDD; cd23272; Dkk1_Cys2; 1.
DR CDD; cd23026; Dkk1_N_Cys1; 1.
DR Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR048500; DIKK1/2/4_C-subdom1.
DR InterPro; IPR048499; DIKK1/2/4_C-subdom2.
DR InterPro; IPR039863; DKK1-4.
DR InterPro; IPR047304; Dkk1_Cys2.
DR InterPro; IPR047305; Dkk1_N.
DR PANTHER; PTHR12113:SF11; DICKKOPF-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
DR Pfam; PF21481; DIKK1-2-4_C-subdom1; 1.
DR Pfam; PF21479; DIKK1-2-4_C-subdom2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 85..139
FT /note="Dickkopf N-terminal cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF04706"
FT DOMAIN 185..214
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 1"
FT /evidence="ECO:0000259|Pfam:PF21481"
FT DOMAIN 217..266
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 2"
FT /evidence="ECO:0000259|Pfam:PF21479"
SQ SEQUENCE 266 AA; 28709 MW; E6EBC90C6A524E7B CRC64;
MMALGAAGAT RVFVALVAAA LGGHPLLGVS ATLNSVLNSN AIKNLPPPLG GAAGHPGSAV
SAAPGILYPG GNKYQTIDNY QPYPCAEDQE CGTDEYCASP TRGGDAVVQI CLACRKRRKR
CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH
TKGQEGSVCL RSSDCATGLC CARHFWSKIC KPVLKEGQVC TKHRRKGSHG LEIFQRCYCG
EGLSCRIQKD HHQASNSSRL HTCQRH
//
