ID H2NED8_PONAB Unreviewed; 147 AA.
AC H2NED8; A0A2J8SVX3; A0A663DGF4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Globin B1 {ECO:0000313|EMBL:SAI82158.1};
DE SubName: Full=HBG2 isoform 1 {ECO:0000313|EMBL:PNJ24905.1};
DE SubName: Full=HBG2 isoform 3 {ECO:0000313|EMBL:PNJ24907.1};
GN Name=LOC100438895 {ECO:0000313|Ensembl:ENSPPYP00000004105.1};
GN Synonyms=GLNB1 {ECO:0000313|EMBL:SAI82158.1};
GN ORFNames=CR201_G0039886 {ECO:0000313|EMBL:PNJ24905.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000004105.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000004105.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SAI82158.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2016.10.009;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian globin genes.";
RL Gene Rep 5:163-166(2016).
RN [3] {ECO:0000313|EMBL:PNJ24905.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ24905.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:SAI82158.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [5] {ECO:0000313|Ensembl:ENSPPYP00000004105.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination
CC with alpha chains. {ECO:0000256|ARBA:ARBA00037567}.
CC -!- SIMILARITY: Belongs to the globin family.
CC {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238,
CC ECO:0000256|RuleBase:RU000356}.
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DR EMBL; NDHI03003540; PNJ24905.1; -; Genomic_DNA.
DR EMBL; NDHI03003540; PNJ24907.1; -; Genomic_DNA.
DR EMBL; LT548118; SAI82158.1; -; Genomic_DNA.
DR RefSeq; XP_002822174.1; XM_002822128.3.
DR STRING; 9601.ENSPPYP00000004105; -.
DR Ensembl; ENSPPYT00000004271.2; ENSPPYP00000004105.1; ENSPPYG00000040400.1.
DR GeneID; 100438895; -.
DR KEGG; pon:100438895; -.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000162659; -.
DR HOGENOM; CLU_003827_10_0_1; -.
DR OMA; SELHCER; -.
DR OrthoDB; 5356926at2759; -.
DR TreeFam; TF333268; -.
DR Proteomes; UP000001595; Chromosome 11.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; Globins; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11442:SF52; HEMOGLOBIN SUBUNIT GAMMA-1; 1.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; Globin-like; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000356}; Iron {ECO:0000256|RuleBase:RU000356};
KW Metal-binding {ECO:0000256|RuleBase:RU000356};
KW Oxygen transport {ECO:0000256|ARBA:ARBA00022621,
KW ECO:0000256|RuleBase:RU000356};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transport {ECO:0000256|RuleBase:RU000356}.
FT DOMAIN 2..147
FT /note="Globin family profile"
FT /evidence="ECO:0000259|PROSITE:PS01033"
SQ SEQUENCE 147 AA; 16145 MW; 8146516B27A9DD9E CRC64;
MGHFTEEDKA TITSLWGKLN VEDAGGETLG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPK
VKAHGKKVLT SLGDAIKNLD DLKGTFAQLS ELHCDKLHVD PENFRLLGNV LVTVLAIHFG
KEFTPEVQAS WQKMVTGVAS ALSSRYH
//
