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Database: UniProt
Entry: H2NFU8_PONAB
LinkDB: H2NFU8_PONAB
Original site: H2NFU8_PONAB 
ID   H2NFU8_PONAB            Unreviewed;       466 AA.
AC   H2NFU8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   16-OCT-2019, entry version 47.
DE   SubName: Full=Fli-1 proto-oncogene, ETS transcription factor {ECO:0000313|Ensembl:ENSPPYP00000004633};
GN   Name=FLI1 {ECO:0000313|Ensembl:ENSPPYP00000004633};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000004633, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000004633, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000004633}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; ABGA01368846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01368855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000004633; -.
DR   Ensembl; ENSPPYT00000004814; ENSPPYP00000004633; ENSPPYG00000004052.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000158261; -.
DR   InParanoid; H2NFU8; -.
DR   OMA; GWGSNMN; -.
DR   TreeFam; TF350537; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR   GO; GO:0008015; P:blood circulation; IEA:Ensembl.
DR   GO; GO:0035855; P:megakaryocyte development; IEA:Ensembl.
DR   CDD; cd08541; SAM_PNT-FLI-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR035575; Fli-1.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR035573; SAM_PNT-FLI-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF161; PTHR11849:SF161; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT   DOMAIN      126    212       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      295    375       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      223    285       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      447    466       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    242    285       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   466 AA;  52277 MW;  6A57D7E069611657 CRC64;
     MCGILGGSAA DLAKWTGLLK EALSVVSDDQ SLFDSAYGAA AHLPKADMTA SGSPDYGQPH
     KINPLPPQQE WLNQPVRVNV KREYDHVNGS RESPVDCSVS KCSKLVGGGE SNPMNYNSYM
     DEKNGPPPPN MTTNERRVIV PADPTLWTQD HVRQWLEWAI KEYSLMEIDT SFFQNMDGKE
     LCKMNKEDFL RATTLYNTEV LLSHLSYLRE SSLLAYNTTS HTDQSSRLSV KEDPSYDSVR
     RGAWGNNMNS GLNKSPPLGG AQTISKNTEQ RPQPDPYQIL GPTSSRLANP GSGQIQLWQF
     LLELLSDSAN ASCITWEGTN GEFKMTDPDE VARRWGERKS KPNMNYDKLS RALRYYYDKN
     IMTKVHGKRY AYKFDFHGIA QALQPHPTES SMYKYPSDIS YMPSYHAHQQ KVNFVPPHPS
     SMPVTSSSFF GAASQYWTSP TGGIYPNPNV PRHPNTHVPS HLGSYY
//
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