ID H2NFZ8_PONAB Unreviewed; 344 AA.
AC H2NFZ8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Junctional adhesion molecule 3 {ECO:0000313|Ensembl:ENSPPYP00000004683.3};
GN Name=JAM3 {ECO:0000313|Ensembl:ENSPPYP00000004683.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000004683.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000004683.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000004683.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2NFZ8; -.
DR Ensembl; ENSPPYT00000004868.3; ENSPPYP00000004683.3; ENSPPYG00000004105.3.
DR eggNOG; ENOG502QTVP; Eukaryota.
DR GeneTree; ENSGT00940000156937; -.
DR HOGENOM; CLU_067351_2_0_1; -.
DR InParanoid; H2NFZ8; -.
DR OMA; ELSCIIM; -.
DR TreeFam; TF331459; -.
DR Proteomes; UP000001595; Chromosome 11.
DR GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0030057; C:desmosome; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0033010; C:paranodal junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0098636; C:protein complex involved in cell adhesion; IEA:Ensembl.
DR GO; GO:0043220; C:Schmidt-Lanterman incisure; IEA:Ensembl.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0002250; P:adaptive immune response; IEA:Ensembl.
DR GO; GO:0034333; P:adherens junction assembly; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0045176; P:apical protein localization; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
DR GO; GO:0097530; P:granulocyte migration; IEA:Ensembl.
DR GO; GO:0097241; P:hematopoietic stem cell migration to bone marrow; IEA:Ensembl.
DR GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0002523; P:leukocyte migration involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0002318; P:myeloid progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0033629; P:negative regulation of cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0033624; P:negative regulation of integrin activation; IEA:Ensembl.
DR GO; GO:0001780; P:neutrophil homeostasis; IEA:Ensembl.
DR GO; GO:1905710; P:positive regulation of membrane permeability; IEA:Ensembl.
DR GO; GO:2000439; P:positive regulation of monocyte extravasation; IEA:Ensembl.
DR GO; GO:1902414; P:protein localization to cell junction; IEA:Ensembl.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0090138; P:regulation of actin cytoskeleton organization by cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0090022; P:regulation of neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR CDD; cd20946; IgV_1_JAM1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR042974; JAM-C.
DR PANTHER; PTHR44598; JUNCTIONAL ADHESION MOLECULE C; 1.
DR PANTHER; PTHR44598:SF2; JUNCTIONAL ADHESION MOLECULE C; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 276..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..161
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 173..270
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 344 AA; 38557 MW; C3E879D68A2C6BFA CRC64;
MVTGAGRRGL AGWAHAREDY KLRRAAAGPS ATLDMALRRP PRLRLCARLP DFFLLLLFRG
CLIGAVNLKS SNRTPVVQEF ESVELSCIIT DSQTSDPRIE WKKIQDEQTT YVFFDNKIQG
DLAGRAEILG KTSLKIWNVT RKDSALYRCE VVARNDRKEI DEIVIELTVQ VKPVTPVCRV
PKAVPVGKMA TLHCQESEGH PRPHYSWYRN DVPLPTDSRA NPRFRNSSFH LNSETGTLVF
TAVHKDDSGQ YYCIASNDAG SARCEEQEME VYDLNIGGII GGVLVVLAVL ALITLGICCA
YRRGYFINNK QDGESYKNPG KPDGVNYIRT DEEGDFRHKS SFVI
//
