ID H2NG84_PONAB Unreviewed; 1402 AA.
AC H2NG84; A0A2J8TB67;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Condensin complex subunit 1 {ECO:0000256|PIRNR:PIRNR017127};
GN Name=NCAPD2 {ECO:0000313|Ensembl:ENSPPYP00000004773.3};
GN ORFNames=CR201_G0036250 {ECO:0000313|EMBL:PNJ30243.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000004773.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000004773.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ30243.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ30243.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000004773.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulatory subunit of the condensin complex, a complex
CC required for conversion of interphase chromatin into mitotic-like
CC condense chromosomes. The condensin complex probably introduces
CC positive supercoils into relaxed DNA in the presence of type I
CC topoisomerases and converts nicked DNA into positive knotted forms in
CC the presence of type II topoisomerases.
CC {ECO:0000256|PIRNR:PIRNR017127}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CND1 (condensin subunit 1) family.
CC {ECO:0000256|ARBA:ARBA00009606, ECO:0000256|PIRNR:PIRNR017127}.
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DR EMBL; NDHI03003510; PNJ30243.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000004773; -.
DR Ensembl; ENSPPYT00000004963.3; ENSPPYP00000004773.3; ENSPPYG00000004188.3.
DR eggNOG; KOG0414; Eukaryota.
DR GeneTree; ENSGT00940000153566; -.
DR HOGENOM; CLU_001867_3_1_1; -.
DR OMA; CPLEKLW; -.
DR OrthoDB; 5480287at2759; -.
DR TreeFam; TF105712; -.
DR Proteomes; UP000001595; Chromosome 12.
DR GO; GO:0000793; C:condensed chromosome; IEA:Ensembl.
DR GO; GO:0000796; C:condensin complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000228; C:nuclear chromosome; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007076; P:mitotic chromosome condensation; IEA:Ensembl.
DR GO; GO:1905821; P:positive regulation of chromosome condensation; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026971; CND1/NCAPD3.
DR InterPro; IPR032682; Cnd1_C.
DR InterPro; IPR007673; Condensin_cplx_su1.
DR InterPro; IPR024324; Condensin_cplx_su1_N.
DR PANTHER; PTHR14222; CONDENSIN; 1.
DR PANTHER; PTHR14222:SF2; CONDENSIN COMPLEX SUBUNIT 1; 1.
DR Pfam; PF12717; Cnd1; 1.
DR Pfam; PF12922; Cnd1_N; 1.
DR PIRSF; PIRSF017127; Condensin_D2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR017127};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|PIRNR:PIRNR017127}; Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067,
KW ECO:0000256|PIRNR:PIRNR017127};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|PIRNR:PIRNR017127};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 76..240
FT /note="Condensin complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12922"
FT DOMAIN 1070..1231
FT /note="Condensin complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12717"
FT REGION 576..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1304..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1402 AA; 157069 MW; D67526A4E8F87446 CRC64;
MAPQMYEFHL PLSPEELLKS GGVNQYVVQE VLSIKHLPPQ LRAFQAAFRA QGPLAMLEHF
DTIYSILHHF RSIDPDLKED TLEFLIKVVS RHSQELPAIL DDTTLSGSDR NAHLNALKMN
CYALIRLLES FETMASQTNL VDLDLGGKGK KARTKAAHGF DWEEERQPIL QLLTQLLQLD
IRHLWNHSII EEEFVSLVTG CCYRLLENPT INHQKNRPTR EAITHLLGVA LTRYNHMLSA
TVKIIQMLQH FEHLAPVLVA AVSLWATDYG MKSIVGEIVR EIGQKCPQEL SRDPSGTKGF
AAFLTELAER VPAILMSSMC ILLDHLDGEN YMMRNAVLAA MAEMVLQVLS GDQLEAAARD
TRDQFLDTLQ AHGHDVNSFV RSRVLQLFTR IVQQKALPLT RFQAVVALAV GRLADKSVLV
CKNAIQLLAS FLANNPFSCK LSDTDLAGPL QKETQKLQEM RAQRRTAAAS AVLDPEEEWE
AMLPELKSTL QQLLQLPQGE EEIAEPIANT ETTKDVKGRI YQLLAKASYK QAVILTREAT
GHFQESEPFS HIDPEESEET RLLNILGLIF KGSAASTQEK NPRESTGNMV TGQTVCENKP
NVSEPEESRG NDELVKQEML VQYLQDAYSF SRKITEAIGI ISKMMYENTT TVVQEVIEFF
VMVFQFGVPQ ALFGVRRMLP LIWSKEPGIR EAVLNAYRQL YLNPKGDSAR AKAQALIQNL
SLLLVDASVG TIQCLEEILC EFVQKDELKP AVTQLLWERA TEKVACCPLE RCSSVMLLGM
MARGKPEIVG SNLDTLVSIG LDEKFPQDYR LAQQVCHAIA NISDRRKPSL GKRHPPFRLP
QEHRLFERLR ETVTRGFVHP DPLWIPFKEV AVTLIYQLAE GSEVICAQIL QDCAKQALEK
LEEKRTSQED PKSSPAMLPT FLLMNLLSLA GDVALQQLVH LEQAVSGELC RRRVLREEQE
HKTKDPKEKN TSSETAMEED LGLVGAAADD TEAELIRGIC EMELLDGKQT LAAFVPLLLK
VCNNPGLYSN PDLSAAASLA LGKFCMISAT FCDSQLRLLF TMLEKSPLPI VRSNLMVATG
DLAIRFPNLV DPWTPHLYAR LRDPAQQVRK TAGLVMTHLI LKDMVKVKGQ VSEMAVLLID
PEPQIAALAK NFFNELSHKG NAIYNLLPDI ISRLSDPELG VEEEPFHTIM KQLLSYITKD
KQTESLVEKL CQRFRTAQTE RQQRDLAYCV SQLPLTERGL RKMLDNFDCF GDKLSDESIF
SAFLSVVGKL RRGAKPEGKA VIDEFEQKLR ACHTRGLDGI EELEIGQAGS QRAPSAKKPS
TGSRHQPLAS TASDKDFVTP EPPCCTTRRH PNTQQRASKK KPKVVFSSDE SSEEDLSAEM
TEDETPKKTT PILRASARRH RS
//
