ID H2NIF8_PONAB Unreviewed; 2551 AA.
AC H2NIF8; A0A2J8XM82;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=STAB2 isoform 1 {ECO:0000313|EMBL:PNJ83146.1};
DE SubName: Full=Stabilin 2 {ECO:0000313|Ensembl:ENSPPYP00000005576.3};
GN Name=STAB2 {ECO:0000313|Ensembl:ENSPPYP00000005576.3};
GN ORFNames=CR201_G0001266 {ECO:0000313|EMBL:PNJ83146.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000005576.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000005576.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ83146.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ83146.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000005576.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; NDHI03003364; PNJ83146.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000005576; -.
DR Ensembl; ENSPPYT00000005790.3; ENSPPYP00000005576.3; ENSPPYG00000004885.3.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000156566; -.
DR HOGENOM; CLU_001035_0_0_1; -.
DR OMA; RDCVEIN; -.
DR TreeFam; TF331489; -.
DR Proteomes; UP000001595; Chromosome 12.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:Ensembl.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0030214; P:hyaluronan catabolic process; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR CDD; cd03515; Link_domain_TSG_6_like; 1.
DR Gene3D; 2.30.180.10; FAS1 domain; 7.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR036378; FAS1_dom_sf.
DR InterPro; IPR000782; FAS1_domain.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR24038; STABILIN; 1.
DR PANTHER; PTHR24038:SF0; STABILIN-2; 1.
DR Pfam; PF12947; EGF_3; 11.
DR Pfam; PF02469; Fasciclin; 7.
DR Pfam; PF00193; Xlink; 1.
DR SMART; SM00181; EGF; 22.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00180; EGF_Lam; 5.
DR SMART; SM00554; FAS1; 7.
DR SMART; SM00445; LINK; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF82153; FAS1 domain; 7.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 18.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50213; FAS1; 7.
DR PROSITE; PS01241; LINK_1; 1.
DR PROSITE; PS50963; LINK_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2551
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197897"
FT TRANSMEM 2460..2483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..148
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 156..193
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 195..236
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 237..276
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 322..362
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 371..505
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 515..652
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 736..776
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 826..866
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 867..909
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 910..952
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 994..1127
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1137..1265
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1346..1384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1391..1428
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1432..1470
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1471..1512
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1513..1554
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1555..1594
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1596..1724
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1740..1881
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1958..1998
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2005..2042
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2123..2165
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2198..2291
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 2311..2446
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT REGION 2512..2551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 138..147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 164..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 183..192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 766..775
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1374..1383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1399..1416
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1418..1427
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1436..1446
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1988..1997
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2032..2041
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2220..2289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 2244..2265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 2551 AA; 276579 MW; AC246A5DE6052123 CRC64;
IMLQHLVIFC LGFVVQNFCS PAETTGQARR CDRKSLLTIR TECRSCALNL GVKCPDGYTK
ITSGSVGVRD CRYTFEVRTY SLSLPGCRHI CRKDYLQPQC CPGHWGPDCI ECPGGAGSPC
NGRGSCAEGM EGNGTCSCQE GFGGTACETC ADDNLFGPSC SSVCNCVHGV CNSGLDGDGT
CECYSAYTGP KCDKPIPECA ALLCPENSRC LPSTEDENKL ECKCLPNYQG NGKYCKPINP
CLQKICHPHA HCTYLGPNRH SCTCQEGYRG DGQVCLPVDP CQINFGNCPT KSTVCKYDGP
GQSHCECKEH YQNFIPGVGC SMTDICKSDN LCHRNANCTT VAPGRTECVC QKGYVGDGLT
CYGNIMERLR ELNTEPRGKW QGRLTSFISL LDKAYAWPLS KLGPFTVLLP TDKGLKGFNV
NELLVDNKAA QYFVKLHIIA GQMNTEYMNN TDTFYTLTGK SGEIFNSDKD NQIKLKLHGG
KKKVKIIQGD IIASNGLLHI LDRAMDKLEP TFESNNEQTI MTMLQPRYSK FRSLLEETNL
GHALDEDGVG GPYTIFVPSN EALNNMKDGT LDYLLSPEGS RKLLELVRYH IVPFTQLEVA
TLISTPHIRS MANQLIQFNT TDNGQILAND VAMEEIEITA KNGRIYTLTG VLIPPSIVPI
LPHRCDETKR EMKLGTCVSC SLVYWSRCPA NSEPTALFTH RCVYSGRFGS LKSGCARYCN
ATVKIPKCCK GFYGPDCNQC PGGFSNPCSG NGQCADSLGG NGTCICEEGF QGSQCQFCSD
PNKYGPRCNK KCLCVHGTCN NRIDSDGACL PGTCRDGSAG RLCDKQTSAC GPYVQFCHIH
ATCEYSNGTA SCICKAGYEG DGTVCSEMDP CTGLTPGGCS RNAECIKTGT GTHTCVCQQG
WTGNGRDCLE INNCLLPSAG GCHDNATCLY VGPGQNECEC KKGFRGNGID CEPITSCLEQ
TGKCHPLANC QSTTSGIWSC VCQEGYEGDG FLCYGNAAVE LSFLSEAAVF NRWINNASLQ
PTLSATSNLT VLVPSQQATE DMDQDEKSFW LSQSNIPALI KYHMLLGTYR VADLQTLSSS
DMLATSLQGN FLHLAKVDGN ITIEGASIVD GDNAATNGVI HIINKVLVPQ RRLTGSLPNL
LMRLEQMPDY SIFRGYIIQY NLANAIEAAD AYTVFAPNNN AIENYIREKK VLSLEEDVLR
YHVVLEEKLL KNDLHNGMHR ETMLGFSYFL GFFLHNDQLY VNEAPINYTN VATDKGVIHG
LGKVLEIQKN RCDNNDTTII RGRCRTCSSE LICPFGTKSL GNEKRRCIYT SYFMGRRTLF
IGCQPKCVRT VITRECCAGF FGPQCQPCPG NAQNVCFGNG ICLDGVNGTG VCECGEGFSG
TACETCTEGK YGIHCDQVCS CVHGRCNQGP LGDGSCDCDV GWRGVHCENA TTEDNCNGTC
HTSANCLPNS DGKASCKCAA GFQGNGTICT AINACEISNG GCSAKADCKR TTPGSRVCTC
KAGYTGDGIV CLEINPCLEN HGGCDKNAEC TQTGPNQAAC NCLPAYTGDG KVCTLINVCL
TKNGGCSEFA ICNHTGQGER TCTCKPNYIG DGFTCRGSIY QELPKNPKTS QYFFQLQEHF
VKDLVGPGPF TVFAPLSAAF DEEARVKDWD KQGLMPQVLR YHVVACHQLL LENLKLISNA
TSLQGEPIVI SVSQGTVYIN NKAKIISSDI ISTNGIVHII DKLLSPKNLL ITPKDTSGRI
LQNLTTLATN NGYIKFSNLI QDSGLLSVIT DPIHTPVTLF WPTDQALHAL PAEQQDFLFN
QDNKDKLKEY LKFHVIRDAK VLAVDLPTST AWKTLQGSEL SVKCGAGSDI GDLFLNGQTC
RIVQRELLFD LGVAYGIDCL LIDPTLGGRC DTFTTFDASG ECGSCVNTPS CPRWSKPKGV
KQKCLYNLPF KRNLEGCRER CSLVIQIPRC CKGYFGRDCQ ACPGGPDAPC NNRGVCLDQY
SATGECKCNT GFNGTACEMC WPGRFGPDCL PCGCSDHGQC DDGITGSGQC LCETGWTGPS
CDTQAVLPAV CMPPCSAHAT CKENNTCECN LDYEGDGITC TVVDFCKQDN GGCAKVARCS
QKGTKVSCSC QKGYKGDGHS CTEIDPCADG LNGGCHEHAT CKMTGPGKHK CECKSHYVGD
GLNCEPEQLP IDRCLQDNGH CHADAKCVDL HFQDTTVGVF HLRSPLGQYK LTFDKARDAC
ANEAATMATY NQLSYAQKAK YHLCSAGWLE SGRVAYPTAF ASQNCGSGVV GIVDYGPRPN
KSEMWDVFCY RMKDVNCTCK AGYVGDGFSC SGNLLQVLMS FPSLTNFLTE VLAYSNSSAR
GRAFLEHLTD LSIRGTLFVP QNSGLGENET LSGQDIEHHL ANVSMFFYND LVNGTTLQTR
LGSKLLITAS QDPLQPTETR FVDGRAILQW DIFASNGIIH VISRPLKAPP APMTLTHTGL
GAGIFFAIIL VIGAAALAAY SYFRINRRTI GFQHFESEED INVAALGKQQ PENISNPLYE
STTSAPPEPS YDPFTDSEEQ QLEGNDPLGT L
//
