ID H2NIF9_PONAB Unreviewed; 548 AA.
AC H2NIF9; A0A2J8XM81; A0A6D2W1X2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=5'-nucleotidase domain containing 3 {ECO:0000313|Ensembl:ENSPPYP00000005577.2};
DE SubName: Full=NT5DC3 isoform 1 {ECO:0000313|EMBL:PNJ83143.1};
GN Name=NT5DC3 {ECO:0000313|Ensembl:ENSPPYP00000005577.2};
GN ORFNames=CR201_G0001263 {ECO:0000313|EMBL:PNJ83143.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000005577.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000005577.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ83143.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ83143.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000005577.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR017434-2};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR017434-2};
CC -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
CC {ECO:0000256|ARBA:ARBA00009589}.
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DR EMBL; NDHI03003364; PNJ83143.1; -; Genomic_DNA.
DR RefSeq; XP_009246440.1; XM_009248165.1.
DR STRING; 9601.ENSPPYP00000005577; -.
DR Ensembl; ENSPPYT00000005791.3; ENSPPYP00000005577.2; ENSPPYG00000004886.3.
DR GeneID; 100450020; -.
DR KEGG; pon:100450020; -.
DR CTD; 51559; -.
DR eggNOG; KOG2470; Eukaryota.
DR GeneTree; ENSGT00940000158637; -.
DR HOGENOM; CLU_017845_5_1_1; -.
DR OMA; WSRYKEA; -.
DR OrthoDB; 3626840at2759; -.
DR TreeFam; TF323990; -.
DR Proteomes; UP000001595; Chromosome 12.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07522; HAD_cN-II; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR016695; Pur_nucleotidase.
DR NCBIfam; TIGR02244; HAD-IG-Ncltidse; 1.
DR PANTHER; PTHR12103; 5'-NUCLEOTIDASE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR12103:SF11; 5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF05761; 5_nucleotid; 1.
DR PIRSF; PIRSF017434; Purine_5'-nucleotidase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|PIRSR:PIRSR017434-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR017434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT REGION 528..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 102
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-1"
FT ACT_SITE 104
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-1"
FT BINDING 102
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
FT BINDING 104
FT /ligand="GMP"
FT /ligand_id="ChEBI:CHEBI:58115"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
FT BINDING 389
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
SQ SEQUENCE 548 AA; 63420 MW; 93B1C8CD7C2E0434 CRC64;
MTMAAAAVVA RGAGARAATA AALRGGCGTA ARGRPCAGPA RPLCTAPGTA PDMKRYLWER
YREAKRSTEE LVPSIMSNLL NPDAIFSNNE MSLSDIEIYG FDYDYTLVFY SKHLHTLIFN
AARDLLINEH RYPAEIRKYE YDPNFAIRGL HYDVQRAVLM KIDAFHYIQL GTVYRGLSVV
PDEEVIEMYE GSHVPLEQMS DFYGKSSHGN TMKQFMDIFS LPEMTLLSCV NEYFLKNNID
YEPVHLYKDV KDSIRDVHIK GIMYRAIEAD IEKYICYAEQ TRAVLAKLAD HGKKMFLITN
SPSSFVDKGM SYIVGKDWRD LFDVVIVQAE KPNFFNDKRR PFRKMNEKGV LLWDKIHKLQ
KGQIYKQGNL YEFLKLTGWR GSRVLYFGDH IYSDLADLTL KHGWRTGAII PELRSELKIM
NTEQYIQTMT WLQTLTGLLE QMQVHRDAES QLVLQEWKKE RKEMREMTKS FFNAQFGSLF
RTDQNPTYFL RRLSRFADIY MASLSCLLNY DVSHTFYPRR TPLQHELPAW SERPPTFGTP
LLQEAQAK
//
