ID H2NM87_PONAB Unreviewed; 834 AA.
AC H2NM87; A0A2J8TLB5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=EMAP like 1 {ECO:0000313|Ensembl:ENSPPYP00000006976.2};
DE SubName: Full=EML1 isoform 2 {ECO:0000313|EMBL:PNJ33774.1};
GN Name=EML1 {ECO:0000313|Ensembl:ENSPPYP00000006976.2};
GN ORFNames=CR201_G0033891 {ECO:0000313|EMBL:PNJ33774.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000006976.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000006976.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ33774.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ33774.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000006976.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; NDHI03003491; PNJ33774.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000024054; -.
DR Ensembl; ENSPPYT00000007251.2; ENSPPYP00000006976.2; ENSPPYG00000006137.3.
DR GeneTree; ENSGT00940000153887; -.
DR HOGENOM; CLU_011754_0_0_1; -.
DR OMA; ICCADFH; -.
DR Proteomes; UP000001595; Chromosome 14.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR GO; GO:1990023; C:mitotic spindle midzone; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR CDD; cd21947; TD_EMAP1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF22; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 207..278
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 558..590
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 687..718
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 799..834
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 97..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 31..72
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 127..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 92040 MW; 6DC45BE4E1811121 CRC64;
MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVTDRIAS LEQRVQMQED DIQLLKSALA
DVVRRLNITE EQQAVLNRKG PTKARPLMQT LPLRTTVNNG TVLPKKPTGS LPSPSGVRKE
TAVPATKRLN RSVSLLNACK LNRSTPSNIK RTSSSERVSP GGRRESNGDS RGNRNRTGST
SSSSSGKKNS ESKPKEPVFS AEEGYVKMFL RGRPVTMYMP KDQVDSYSLE AKVELPTKRL
KLEWVYGYRG RDCRNNLYLL PTGETVYFIA SVVVLYNVEE QLQRHYAGHN DDVKCLAVHP
DRITIATGQV AGTSKDGKQL PPHVRIWDSV TLNTLHVIGI GFFDRAVTCI AFSKSNGGTN
LCAVDDSNDH VLSVWDWQKE EKLADVKCSN EAVFAADFHP TDTNIIVTCG KSHLYFWTLE
GSSLNKKQGL FEKQEKPKFV LCVTFSENGD TITGDSSGNI LVWGKGTNRI SYAVQGAHEG
GIFALCMLRD GTLVSGGGKD RKLISWSGNY QKLRKTEIPE QFGPIRTVAE GKGDVILIGT
TRNFVLQGTL SGDFTPITQG HTDELWGLAI HASKPQFLTC GHDKHATLWD AVGHRPVWDK
IIEDPAQSSG FHPSGSVVAV GTLTGRWFVF DTETKDLVTV HTDGNEQLSV MRYSPDGNFL
AIGSHDNCIY IYGVSDNGRK YMRVGKCSGH SSFITHLDWS INSQFLVSNS GDYEILYWVP
SACKQVVSVE TTRDIEWATY TCTLGFHVFG VWPEGSDGTD INAVCRAHEK KLLSTGDDFG
KVHLFSYPCS QFRAPSHIYG GHSSHVTNVD FLCEDSHLIS TGGKDTSIMQ WRVI
//
