GenomeNet

Database: UniProt
Entry: H2NMQ0_PONAB
LinkDB: H2NMQ0_PONAB
Original site: H2NMQ0_PONAB 
ID   H2NMQ0_PONAB            Unreviewed;      4565 AA.
AC   H2NMQ0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPPYP00000007144};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSPPYP00000007144};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000007144, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000007144, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000007144}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01252357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01252366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000007144; -.
DR   Ensembl; ENSPPYT00000007440; ENSPPYP00000007144; ENSPPYG00000006305.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   InParanoid; H2NMQ0; -.
DR   OMA; PLLNEYC; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001595; Chromosome 15.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3882   3906       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4106   4126       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4174   4193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4305   4323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4366   4387       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4446   4469       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      584    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1207       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     4028   4055       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4565 AA;  517119 MW;  D6ED89D9E762883B CRC64;
     MAELGGGGEE DARWYRKEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHVAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QHEESQAARI IRNTTALFSQ
     FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSILEV LHCILTESPE ALNLIAEGHI KSIISLLDKH GRNHKVLDIL
     CSLCLCNGVA VRANQNLICD NLLPRRNLLL QTRLINDVTS IRPNIFLGVA EGSAQYKKWY
     FELIIDQVDP FLTAEPTHLR VGWASSSGYA PYPGGGEGWG GNGVGDDLYS YGFDGLHLWS
     GRIPRAVASI NQHLLRSDDV VSCCLDLGVP SISFRINGQP VQGMFENFNT DGLFFPVMSF
     SAGVKVRFLM GGRHGEFKFL PPSGYAPCYE ALLPKEKMRL EPVKEYKRDA DGVRDLLGTT
     QFLSQASFIP CPIDTSQVVL PPHLEKIRDR LAENIHELWG MNKIELGWTF GKIRDDNKRQ
     HPCLVEFSKL PETEKNYNLQ MSTETLKTLL ALGCHIAHVN LAAEEDLKKV KLPKNYMMSN
     GYKPAPLDLS DVKLLPPQEI LVDKLAENAH NVWAKDRIKQ GWTYGIQQDL KNKRNPRLVP
     YALLDERTKK SNRDSLREAV RTFVGYGYNI EPSDQELADS AVEKVSIDKI RFFRVERSYA
     VRSGKWYFEF EVVTGGDMRV GWARPGCRPD VELGADDQAF VFEGNRGQRW HQGSGYFGRT
     WQPGDVVGCM INLDDASMIF TLNGELLITN KGSELAFADY EIENGFVPIC CLGLSQIGRM
     NLGTDASTFK FYTMCGLQEG FEPFAVNMNR DVAMWFSKRL PTFVNVPKDH PHIEEMRIDG
     TMDSPPCLKV THKTFGTQKS NADMIYCRLS MPVECHSSFS HSPCLDSEAF QKRKQMQEIL
     SHTTTQCYYA IRIFAGQDPS CVWVGWVTPD YHLYSEKFDL NKNCTVTVTL GDERGRVHES
     VKRSNCYMVW GGDIVASSQR SNRSNVDLEI GCLVDLAMGM LSFSANGKEL GTCYQNALPL
     SAAIFKSEEK NPVPQCPPRL DVQTIQPVLW SRMPNSFLKV ETERVSERHG WVVQCLEPLQ
     MMALHIPEEN RCVDILELCE QEDLMRFHYH TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF
     YAIDNKYLPG LLRSGFYDLL ISIHLANAKE RKLMMKNEYI IPITSTTRNI RLFPDESKRH
     GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ KQSPEIPLES LRTKALSMLT EAVQCSGAHI
     RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD DDVRQILLLI DPSVFGEHSA GTEEGAEKEE
     VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG
     DIYVSKLQAN QKFRYNELMQ ALNMSAALTA RKTKEFRSPP QEQINMLLNF QLGENCPCPE
     EIREELYDFH EDLLLHCGVP LEEEEEEEED TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE
     RCPTTLKELI SQTMICWAQE DQIQDSELVR FFFDLLRRQY DSIGELLQAL RKTYTIFHTS
     VSDTINLLAA LGQIRSLLSV RMGKEEELLM INGLGDIMNN KVFYQHPNLM RVLGMHETVM
     EVMVNVLGTE KSQSPSMRGS TPLDVAASSV MDNNELALSL EEPDLEKVVT YLAGCGLQSC
     PMLLAKGYPD VSWNPIEGER YLSFLRFAVF VNSESVEENA SVVVKLLIRR PECFGPALRG
     EGGNGLLAAM QGAIKISENP ALDLPSQGYK REVSTEDDEE EEEIVHMGNA IMSFYSALID
     LLGRCAPEMH LIQTGKGEAI RIRSILRSLV PTEDRDGIIS IPLKLPSLNK DGSVSEPDMA
     ANFCPDHKAP MVLFLDRVYG IKDQTFLLHL LEVGFLPDLR ASASLDTVSL STTEAALALN
     RYICSAVLPL LTRCAPLFAG TEHCTSLIDS TLQTIYRLSK GRSLTKAQRD TIEECLLAIC
     NHLRPSMLQQ LLRRLVFDVP QLNEYCKMPL KLLTNHYEQC WKYYCLPSGW GSYGLAVEEE
     LHLTEKLFWG IFDSLSHKKY DPDLFRMALP CLSAIAGALP PDYLDTRITA TLEKQISVDA
     DGNFDPKPIN TMSQSGWKYG ISLDENVKTH PLIRPFKTLT EKEKEIYRWP ARESLKTMLA
     VGWTVERTKE GEALVQQREN EKLRSVSQAN QGNSYSPAPL DLSNVVLSRE LQGMVEVVAE
     NYHNIWAKKK KLELESKGGG SHPLLVPYDT LTAKEKFKDR EKAQDLFKFL QVNGVIVSRG
     MKDMELDASS MEKRFAYKFL KKILKYVDSA QEFIAHLEAI VSSGKTEKSP HDQEIKFFAK
     VLLPLVDQYF TNHRLYFLSS PLKPLSSSGY ASHKEKEMVA SLFCKLAALV RHRISLFGND
     STTMVSCLHI LAQTLDTRTV MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT
     QIKGVSQNIN YTTVALLPIL TSIFEHVTQH QFGMDLLLGD VQISCYHILC SLYSLGTGKN
     IYVERQRPAL GECLASLAAA IPVAFLEPTL NRYNPLSVFN TKTPRERSIL GMPDTVEDMC
     PDIPQLEGLM KEINDLAESG ARYTEMPHVI EVILPMLCNY LSYWWERGPE NLPPSTGPCC
     TKVTSEHLSL ILGNILKIIN NNLGIDEASW MKRIAVYAQP IISKARPDLL RSHFIPTLEK
     LMKNAVKTVQ EEQLKADGKG DTQAELLILD EFAVLCRDLY AFYPMLIRYV SNWLKSPDAD
     SDQLFRMVAE VFILWCKSHN FKREEQNFVI QNEINNLAFL TGDSKSKMSK VISAASGGQD
     QERKKTKRRG DFYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKSRY SHRDTDEEVR
     EHLRNNLHLQ EKSDDPAVKW QLNLYKDVLK SEEPFNPEKT VERVQRISAA VFHLEQVEQP
     LRSKKAVWHK LLSKQRKRAV VACFRMAPLY NLPHRSINLF LHGYQRFWIE TEEYSFEEKL
     VQDLAKSPKV EEEEEEETEK QPDPLHQIIL YFSRNALTER SKLEDDPLYT SYSSMMAKSC
     QSGEDEEEDE DKEKTFEEKE MEKQKTLYQQ ARLHERGAAE MVLQMISASK GEMSPMVVET
     LKLGIAILNG GNAGVQQKML DYLKEKKDAG FFQSLSGLMQ SCSVLDLNAF ERQNKAEGLG
     MVTEEGTLIV RERGEKVLQN DEFTRDLFRF LQLLCEGHNS DFQNFLRTQM GNTTTVNVII
     STVDYLLRLQ ESISDFYWYY SGKDIIDESG QHNFSKALAV TKQIFNSLTE YIQGPCIGNQ
     QSLAHSRLWD AVVGFLHVFA NMQMKLSQES CRSHGEKPHL KDSRQFIFDV VEGGEQDSME
     LFVNFCEDFF EMHAASQISE SDSADRPEEA EEDEDSSYVL IAGEEEEDGS FEPGSAFAMA
     CASVMRIVSD FLKKAPLKNL TKHYRNVKNM TAKELVKVLF SFFWMLFVGL FQLLFSILGG
     IFHILWSTVF GGGLVEGAKN IRVTKILGDM PDPTQFGIHD DTMEAERAEV MEPGITTELV
     HFIKGEKGDT DIMSDLFGLH PKKEGSLKHG PEVGLGDLSE IIGKDEPPTL ESTVQKKRKA
     QAAEMKAANE AEGKVESEKA DMEDGEKEDK DKEEEQAEYL WTEVTKKKKR RCGQKVEKLE
     AFTANFFKGL EIYQTKLLHY LARNFYNLRF LALFVAFAIN FILLFYKVTE EPLEEETEDV
     ANLWNSFNDE EEEEAMVFFV LQESTGYMAP TLRALAIIHT IISLVCVVGY YCLKVPLVVF
     KREKEIARKL EFDGLYITEQ PSEDDIKGQW DRLVINTPSF PNNYWDKFVK RKVINKYGDL
     YGAERIAELL GLDKNALDFS PVEETKAEAA SLVSWLSSID MKYHIWKLGV VFTDNSFLYL
     AWYTTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT
     VVAFNFFRKF YNKSEDDDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDPYEMY
     RIVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE DMETKCFICG IGNDYFDTTP
     HGFETHTLQE HNLANYLFFL MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY
     EDQLG
//
DBGET integrated database retrieval system