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Database: UniProt
Entry: H2NP52_PONAB
LinkDB: H2NP52_PONAB
Original site: H2NP52_PONAB 
ID   H2NP52_PONAB            Unreviewed;      1328 AA.
AC   H2NP52;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   12-SEP-2018, entry version 35.
DE   SubName: Full=Fanconi anemia complementation group I {ECO:0000313|Ensembl:ENSPPYP00000007672};
GN   Name=FANCI {ECO:0000313|Ensembl:ENSPPYP00000007672};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000007672, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000007672, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000007672}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; ABGA01281625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01281626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01281627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01281628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01281629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01281630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002825846.1; XM_002825800.3.
DR   STRING; 9601.ENSPPYP00000007672; -.
DR   Ensembl; ENSPPYT00000007984; ENSPPYP00000007672; ENSPPYG00000006762.
DR   GeneID; 100434341; -.
DR   KEGG; pon:100434341; -.
DR   CTD; 55215; -.
DR   eggNOG; KOG4553; Eukaryota.
DR   eggNOG; ENOG410XSU9; LUCA.
DR   GeneTree; ENSGT00390000005855; -.
DR   InParanoid; H2NP52; -.
DR   KO; K10895; -.
DR   OMA; ANETFCL; -.
DR   OrthoDB; EOG091G03X7; -.
DR   TreeFam; TF323694; -.
DR   Proteomes; UP000001595; Chromosome 15.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0070182; F:DNA polymerase binding; IEA:Ensembl.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   CDD; cd11720; FANCI; 1.
DR   InterPro; IPR026171; FANCI.
DR   InterPro; IPR029310; FANCI_HD1.
DR   InterPro; IPR029312; FANCI_HD2.
DR   InterPro; IPR029308; FANCI_S1.
DR   InterPro; IPR029305; FANCI_S1-cap.
DR   InterPro; IPR029315; FANCI_S2.
DR   InterPro; IPR029313; FANCI_S3.
DR   InterPro; IPR029314; FANCI_S4.
DR   PANTHER; PTHR21818; PTHR21818; 1.
DR   Pfam; PF14679; FANCI_HD1; 1.
DR   Pfam; PF14680; FANCI_HD2; 1.
DR   Pfam; PF14675; FANCI_S1; 1.
DR   Pfam; PF14674; FANCI_S1-cap; 1.
DR   Pfam; PF14676; FANCI_S2; 1.
DR   Pfam; PF14677; FANCI_S3; 1.
DR   Pfam; PF14678; FANCI_S4; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT   DOMAIN        1     53       FANCI_S1-cap. {ECO:0000259|Pfam:PF14674}.
FT   DOMAIN       64    280       FANCI_S1. {ECO:0000259|Pfam:PF14675}.
FT   DOMAIN      284    370       FANCI_HD1. {ECO:0000259|Pfam:PF14679}.
FT   DOMAIN      378    541       FANCI_S2. {ECO:0000259|Pfam:PF14676}.
FT   DOMAIN      555    785       FANCI_HD2. {ECO:0000259|Pfam:PF14680}.
FT   DOMAIN      804   1032       FANCI_S3. {ECO:0000259|Pfam:PF14677}.
FT   DOMAIN     1046   1294       FANCI_S4. {ECO:0000259|Pfam:PF14678}.
SQ   SEQUENCE   1328 AA;  149335 MW;  95F6DEDBF5E8A54D CRC64;
     MDQKILSLAA EKTADKLQEF LQTLREGDLT NLLQNQAVKG KVAGALLRAI FKGSPCSGEA
     GTLRRRKIYT CCIQLVESGD LQKEIASEII GLLMLEAHHF PGPLLVELAN EFISTVREGS
     LVNGKSLELL PIILTALATK KENLAYGKGV LSGEECKKQL INTLCSGRWD QPYVIQLTSM
     FKDVPLTAEE VEFVVEKALS MFSKMNLQEI PPLVYQLLVL SSKGSRKSVL EGIIAFFSAL
     DKQHNEEQSG DELLDVITVP SGELRHVEGT IILHIVFAIK LDYELGRELV KHLKVGQQGD
     SSNNLSPFSI ALLLSVTRIQ RFQDQVLDLL KTSVVKSFKD LQLLQGSKFL QNLVPHRSYV
     STMILEVVKN SVHSWDHVTQ GLVELGFILM DSYGPKKVLD GKTIETSPSL SRMPNQHACK
     LGANILLETF KIHEMIRQEI LEQVLNRVVT RASSPISHFL DLLSNIVMYA PLVLQSCSSK
     VTEAFDYLSF LPLQTVQRLL KAVQPLLKVS MSMRDSLILV LRKAMFANQL DARKSAVAGF
     LLLLKNFKVL GSLSSSQCSQ SLSVSQVHVD VHSHYNSVAN ETFCLEIMDS LRRCLSQQAD
     VRLMLYEGFY DVLRRNSQLA NSVMQTLLSQ LKQFYEPKPD LLPPLKLEAC ILTQGDKISL
     QEPLDYLLCC IQHCLAWYKN TVIPLQQGEE EEEEEEAFYE DLDDILESIT NRMIKSELED
     FELDKSADFS QSTSIGIKNN ICAFLVMGVC EVLIEYNFSI SSFSKNRFED ILSLFMCYKK
     LSDILNEKAG KGKTKMANRT NDSLLSMKFV SSLLTALFRD SIQSHQESLS VLRSSNEFMR
     YAVNVALQKV QQLKETGHVS GPDGQNPDKI FQNLCDITRV LLWRYTSIPT SVEESGKKEK
     GKSISLLCLE GLQKIFSAVQ QFYQPKIQQF LRALDVTDKE GEEREDADIS VTQRTAFQIR
     QFQRSLLNLL SSQEEDFNSK EALLLVTVLT SLSKLLEPSS PQFVQMLSWT SKICKENRRE
     DALFCKSLMN LLFSLHVSYK SPVILLRDLS QDIHGHLGDI DQDVEVEKTN HFAMVNLRTA
     APTVCLLVLS QAEKVLEEVD WLITKLKGQV SQETLSKEAS SQATIPNQPV EKAIIMQLGT
     LLTFFHELVQ TALPSGSCVD TLLKDLCKMY TTLTALVRYY LQVCQSSGGI PKNMEKLVKL
     SGSHLTPLCY SFISYVQNKS KSLNYTGEKK EKPAAVATAM ARVLRETKPI PNLIFAIEQY
     EKFLIHLSKK SKVNLMQHMK LSTSRDFKIK GNILDMVLRE DGEDENEEGT ASDHGGQNKE
     PAKKKRKK
//
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