ID H2NR17_PONAB Unreviewed; 848 AA.
AC H2NR17; A0A2J8VZI9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=KIFC3 {ECO:0000313|Ensembl:ENSPPYP00000008360.3};
GN ORFNames=CR201_G0014643 {ECO:0000313|EMBL:PNJ62903.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000008360.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000008360.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ62903.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ62903.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000008360.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR EMBL; NDHI03003406; PNJ62903.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000008701.3; ENSPPYP00000008360.3; ENSPPYG00000007398.3.
DR eggNOG; KOG0239; Eukaryota.
DR GeneTree; ENSGT00940000154022; -.
DR HOGENOM; CLU_001485_12_6_1; -.
DR TreeFam; TF105238; -.
DR Proteomes; UP000001595; Chromosome 16.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01366; KISc_C_terminal; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47972:SF5; KINESIN-LIKE PROTEIN KIFC3; 1.
DR PANTHER; PTHR47972; KINESIN-LIKE PROTEIN KLP-3; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 467..790
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 128..254
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 301..367
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 426..453
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 52..68
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 550..557
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 848 AA; 94232 MW; 481717452A7B0E85 CRC64;
MCASACKDTA ARCPEEAAEP QAMVPSRRTW NLGATPSLRG LWRVGRAPEP EPGMARPAPA
PASPAARPFP HTGPGRLRTG RGKDTPVCGD EDSSARSAAR PALAQCRALS VDWAGPGSPH
GLYLTLQVEH LKEKLISQAQ EVSRLRSELG GTDLEKHRDL LMVENERLRQ EMRRCEAELQ
ELRAKPAGPC PGCEHSQESA QLRDKLSQLQ LEMAESKGML SELNLEVQQK TDRLAEVELR
LKDCLAEKAQ EEERLSRRLR DSHETIASLR AQSPPVKYVI KTVEVESSKT KQALSESQAR
NQHLQEQVAM QRQVLKEMEQ QLQSSHQLTA RLRAQIAMYE SELERAHGQM LEEMQCLEED
KNRAIEEAFA RAQVEMKAVH ENLAGVRTNL LTLQPALRTL TNDYNGLKRQ VRGFPLLLQE
ALRSVKAEIG QAIEEVNSNN QELLRKYRRE LQLRKKCHNE LVRLKGNIRV IARVRPVTKE
DGEGPEATNA VTFDADDDSI IHLLHKGKPV SFELDKVFSP QASQQDVFQE VQALVTSCID
GFNVCIFAYG QTGAGKTYTM EGTAENPGIN QRALQLLFSE VQEKASDWEY TITVSAAEIY
NEVLRDLLGK EPQEKLEIRL CPDGSGQLYV PGLTEFQVQS VDDINKVFEF GHTNRTTEFT
NLNEHSSRSH ALLIVTVRGV DCSTGLRTTG KLNLVDLAGS ERVGKSGAEG SRLREAQHIN
KSLSALGDVI AALRSRQGHV PFRNSKLTYL LQDSLSGDSK TLMVVQVSPV EKNTSETLYS
LKFAERVRSV ELGPGLRRAE LGSWSSQEHL EWEPACQTPQ PSARAHSAPS SGTSSRPGSI
RRKLQPSA
//
