ID H2NRF8_PONAB Unreviewed; 747 AA.
AC H2NRF8; A0A2J8VW66;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=MTSS I-BAR domain containing 2 {ECO:0000313|Ensembl:ENSPPYP00000008509.3};
DE SubName: Full=MTSS1L isoform 1 {ECO:0000313|EMBL:PNJ61744.1};
GN Name=MTSS2 {ECO:0000313|Ensembl:ENSPPYP00000008509.3};
GN ORFNames=CR201_G0015335 {ECO:0000313|EMBL:PNJ61744.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000008509.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000008509.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ61744.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ61744.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000008509.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003408; PNJ61744.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000008509; -.
DR Ensembl; ENSPPYT00000008856.3; ENSPPYP00000008509.3; ENSPPYG00000007536.3.
DR eggNOG; ENOG502QRG4; Eukaryota.
DR GeneTree; ENSGT00950000183156; -.
DR HOGENOM; CLU_004805_2_1_1; -.
DR OMA; QDAMFSK; -.
DR TreeFam; TF320619; -.
DR Proteomes; UP000001595; Chromosome 16.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
DR GO; GO:0003785; F:actin monomer binding; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IEA:Ensembl.
DR GO; GO:0097581; P:lamellipodium organization; IEA:Ensembl.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR CDD; cd07643; I-BAR_IMD_MIM; 1.
DR CDD; cd22060; WH2_MTSS1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR030127; MTSS1/MTSS2.
DR PANTHER; PTHR15708; ACTIN BUNDLING/MISSING IN METASTASIS-RELATED; 1.
DR PANTHER; PTHR15708:SF8; PROTEIN MTSS 2; 1.
DR Pfam; PF08397; IMD; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51338; IMD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 1..252
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT REGION 256..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 79925 MW; BAE3D557D3EC654E CRC64;
METAEKECGA LGGLFQAIVN DMKSSYPIWE DFNSKATKLH SQLRTTVLAA VAFLDAFQKV
ADMATNTRGA TRDIGSALTR MCMRHRSIET KLRQFTNALL ESLINPLQER IEDWKKAANQ
LDKDHAKEYK RARHEIKKKS SDTLKLQKKA RKELLGKGDL QPQLDSALQD VNDMYLLLEE
TEKQAVRRAL IEERGRFCTF ITFLQPVVNG ELTMLGEITH LQGIIDDLVV LTAEPHKLPP
ASEQVIKDLK GSDYSWSYQT PPSSPSSSSS RKSSMCSAPS SSSSAKGGGA PWPGGAQTYS
PSSTCRYRSL AQPATSTARL SSVSSHDSGF VSQDAAYSKP PSPMPPDITS QKSSSSASSE
ASETCQSVSE CSSPTSDWSK VSSHEQPSGA TLQRRKDRVE LLRDTEPGPA SGGTLGPSGE
EAPRPRMSPA TIAAKHGEEV SPAASDLAMV LTRGLSLEHQ KSSRDSLQYS SGYSTQTTTP
SCSEDTIPSQ GSDYDCYSVN GDADSEGPPE FDKSSTIPRN SNIAQNYRRL IQTKRPASTA
GLPTAGLPTA TGLPSGAPPG VATIRRTPST KPTVRRALSS AGPIPIRPPI VPVKTPTVPD
SPGYMGPTRA GSEECVFYTD ETASPLAPDL AKASPKRLSL PNTAWGSPSP EAAGYPGAGA
EDEQQQLAAN RHSLVEKLGE LVAGAHALGE GQFPFPTALS ATPTEETPTP PPAATSDPPA
EDMLVAIRRG VRLRRTVTND RSAPRIL
//
