GenomeNet

Database: UniProt
Entry: H2NRJ5_PONAB
LinkDB: H2NRJ5_PONAB
Original site: H2NRJ5_PONAB 
ID   H2NRJ5_PONAB            Unreviewed;      1221 AA.
AC   H2NRJ5; A0A2J8VWL4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   05-JUN-2019, entry version 61.
DE   SubName: Full=ADAMTS18 isoform 2 {ECO:0000313|EMBL:PNJ61931.1};
GN   Name=ADAMTS18 {ECO:0000313|Ensembl:ENSPPYP00000008546};
GN   ORFNames=CR201_G0015433 {ECO:0000313|EMBL:PNJ61931.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000008546, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000008546, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000008546}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:PNJ61931.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ61931.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
RA   Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
RA   Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
RA   Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
RA   Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
RA   Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; ABGA01079992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01079993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01079994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01079995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01079996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01079997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01079998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01079999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01080000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01080001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; NDHI03003408; PNJ61931.1; -; Genomic_DNA.
DR   RefSeq; XP_009249241.1; XM_009250966.1.
DR   STRING; 9601.ENSPPYP00000008546; -.
DR   Ensembl; ENSPPYT00000008894; ENSPPYP00000008546; ENSPPYG00000007572.
DR   GeneID; 100444544; -.
DR   KEGG; pon:100444544; -.
DR   CTD; 170692; -.
DR   eggNOG; KOG3538; Eukaryota.
DR   eggNOG; ENOG410XPKZ; LUCA.
DR   GeneTree; ENSGT00940000157553; -.
DR   InParanoid; H2NRJ5; -.
DR   KO; K08632; -.
DR   OMA; YQERHCN; -.
DR   OrthoDB; 125522at2759; -.
DR   TreeFam; TF313537; -.
DR   Proteomes; UP000001595; Chromosome 16.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0001654; P:eye development; IEA:Ensembl.
DR   GO; GO:0090331; P:negative regulation of platelet aggregation; IEA:Ensembl.
DR   Gene3D; 2.20.100.10; -; 5.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR041645; ADAM_CR_2.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF17771; ADAM_CR_2; 1.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF08686; PLAC; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 6.
DR   SUPFAM; SSF82895; SSF82895; 5.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00117091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17   1221       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014574826.
FT   DOMAIN      293    498       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN     1184   1221       PLAC. {ECO:0000259|PROSITE:PS50900}.
FT   REGION      231    291       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H2NRJ5}.
SQ   SEQUENCE   1221 AA;  135001 MW;  F7B98EBB0047C7B7 CRC64;
     MECALLLACA LPAAGSGPPR GPAGLGRVAK ALQLCCLCCA SVAAALASDS SSGASGLNDD
     YVFVTPVEVD SAGSYISHDI LHNGRKKRSA QNARNSLHYR FSAFGQELHL ELKPSAILSS
     HFIVQVLGKD GASETQKPEV QQCFYQGFIR NDSSSSVAVS TCAGLSGLIR TRKNEFLISP
     LPQLLAQEHN YSSPAGHHPH VLYKRTAEEK VQGYRGYPGS GRNYPGYSPS HIPHASQSQE
     TEYHHRRSQK QHFCGRRKKY APKPPTEDTY LRFDEYGSSG RPRRSAGKSQ KGLNVETLVV
     ADKKMVEKHG KGNVTTYILT VMNMVSGLFK DGTIGSDINV VVVSLILLEQ EPGGLLINHH
     ADQSLNSFCQ WQSALIGKNG KRHDHAILLT GFDICSWKNE PCDTLGFAPI SGMCSKYRSC
     TINEDTGLGL AFTIAHESGH NFGMIHDGEG NPCRKAEGNI MSPTLTGNNG VFSWSSCSRQ
     YLKKFLSTPQ AGCLVDEPKQ GGQYKYPDKL PGQIYDADTQ CKWQFGAKAK LCSLGFVKDI
     CKSLWCHRVG HRCETKFMPA AEGTVCGLSM WCRQGQCVKF GELGPRPIHG QWSAWSKWSE
     CSRTCGGGVK YQERHCNNPK PQYGGKFCPG SSRIYQLCNI NPCNENSLDF RAQQCAEYNS
     KPFRGWFYQW KPYTKVEEED RCKLYCKAEN FEFFFAMSSK VKDGTPCSPN KNDVCIDGVC
     ELVGCDHELG SKAVSDACGV CKGDNSTCKF YKGLYLNQHK ANEYYPVVII PAGARSIEIQ
     ELHVSSSYLA VRSLSQKYYL TGGWSIDWPG EFPFAGTMFE YQRSFNLPER LYAPGPTNET
     LVFEILMQGK NPGIAWKYAL PKVVNGTPPA TKRPAYAWSI VQSECSVSCG GGYINVKAIC
     LRGQNTQVNS SFCSARTKPV TEPKICNAFS CPAYWMPGEW STCSKSCAGG QQSRKIQCVQ
     KKPFQKEEAV LHSLCPVSTP TQVQACNSHA CPPEWSLGPW SQCSKTCGRG VRKRELLCKG
     SATETLPESQ CTSLPRPELQ EGCVLRRCPK NNRLQWVASS WSECSATCGL GVRKREMKCS
     EKGFQGKLIT FPERRCRNIK KPNLDLEETC NRRACPAHPV YNVGAGWYSS PWQQCTVTCG
     GGVQTRSVHC VQQGRPSSSC LLHQKPPVLR ACNTNFCPAP EKREDPSCVD FFNWCHLVPQ
     HGVCNHKFYG KQCCKSCTRK I
//
DBGET integrated database retrieval system