ID H2NSE3_PONAB Unreviewed; 1226 AA.
AC H2NSE3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=USP6 {ECO:0008006|Google:ProtNLM};
GN Name=LOC100433426 {ECO:0000313|Ensembl:ENSPPYP00000008851.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000008851.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000008851.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSPPYT00000009213.2; ENSPPYP00000008851.2; ENSPPYG00000033681.1.
DR eggNOG; KOG1102; Eukaryota.
DR eggNOG; KOG1870; Eukaryota.
DR GeneTree; ENSGT00940000162039; -.
DR HOGENOM; CLU_005123_0_0_1; -.
DR InParanoid; H2NSE3; -.
DR OMA; HDENSST; -.
DR TreeFam; TF324190; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF00443; UCH; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 89..281
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 522..1149
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 337..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1226 AA; 138822 MW; 9E2D753672E91888 CRC64;
MDMIEEADSL QAQEREDIIM KYQKGHRAGL PEDKGPEPVE IYSILCAPLT PKAAQIRQER
KRKNKWLEML GEWETYKNSK KLIDHIYKGV PMNIRGPVWS VLLNIQEIKS KNPRKYKIMK
EKGKRSSEHI HQINLDVSRT LRNHVFFKDR YGAKQRELFY ILLAYSEYNL EVGYCRDLSH
IAALFLLYLP EEDAFWALVQ LLASERHSLP GFHSPNGGTV QGLQDQQEHV VPKSQPKTMW
HQDKEGLCGQ CSSLGCLLRM LIQGISLGLT LRLWDVYLLE GGQVLMPITS IAFKVQKKRL
MKTSRSGRWA RFRNQFFDTW AMDDDTVLKR LRASTKKLTR KQGDLPPPAK PEQGSSAPSP
VPASRGRKTI CKGDRQAPPG PPARFQRPIW PASPPWAPRS STSCPGDAVW EDTYPVGTQG
VPSLALAQGG PQGSWRFLEW NSMPRLPTDL DVGGPWFPHY DFEQSCWVPA ISQEDQLATC
WQAEHSAEGV RLAFTAWPEE MSFIANSSKI DRHKVPIEKG ATGLSNLGNT CFMNSSIQCV
SNTQPLTQYF ISGRHLYELN RTNPIGMKGH MAKCYGDLVQ ELWSGTQKSV APLKLQWTIA
KYAPRFNGFQ QQDSQELLAF LLDGLHEDLN RVHEKPYVEL KDSDGRPDWE VAAEAWDNHL
GRNRSIVVDL FHGQLRSQVK CKTCGHISVR FDPFNFLSLP LPMDSDMHLE ITVIKLDGTT
PVRYGLRLNT DEKYTGLKKQ LSDLCALNSE QILLAEVHDS NIKNFPQDNQ KVGLSVSGFL
CAFEIPVPAS PISASSPTQT DFFSSPSTNG TSTLTTNGDL PRPIFVPSGM PNAVVPCGTE
KNFTNGMVNG HMPSLPDGPF TGYLIAVHRK MMRTELYFLS PQENSPSLFG MPLIVPCTVH
TRKKDLYDAV WMQVSWLASP LPPQEASNHA QDRIGYQYPF TLRVVQKDGN SCAWCPQYRF
CRGCKIDCGE DRAFIGNAYI AVDWDPTALH LRYQMSQERV NKHESVQQSR RTQAKPINLD
SCLRAFTSEE ELGENDMYYC SKCKTHCLAT QKLDLWRLPP FLVCYSPASE RPLHLVFSQF
LRLGSSGSRH CHLISVFFLC PHMADGVKRD RAHRYLQPLY KSPDPNHEVS MFKTISPFEG
PYLLVLSHWQ LSINPFGRET FKPEHDENSS TGRQGSSHQS YSRVMGATLQ NAAQSWGERG
GDKNGTRNRH RSAPCSQDRE EKHQIG
//