ID H2NSN8_PONAB Unreviewed; 465 AA.
AC H2NSN8; A0A2J8RW64;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=KRAB-A domain containing 2 {ECO:0000313|Ensembl:ENSPPYP00000008950.3};
DE SubName: Full=KRBA2 isoform 2 {ECO:0000313|EMBL:PNJ12722.1};
GN Name=KRBA2 {ECO:0000313|Ensembl:ENSPPYP00000008950.3};
GN ORFNames=CR201_G0048006 {ECO:0000313|EMBL:PNJ12722.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000008950.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000008950.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ12722.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ12722.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000008950.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NDHI03003640; PNJ12722.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000008950; -.
DR Ensembl; ENSPPYT00000009316.3; ENSPPYP00000008950.3; ENSPPYG00000007961.3.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT00940000163300; -.
DR HOGENOM; CLU_036427_2_0_1; -.
DR OMA; TAFEDMT; -.
DR OrthoDB; 4265421at2759; -.
DR TreeFam; TF323092; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR45935:SF2; KRAB-A DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45935; PROTEIN ZBED8-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 220..388
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 428..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 53207 MW; 7521BA5C89B2F32D CRC64;
MVPVAEPVLF QEATAFEDMT KDWNYLEGSQ KDCYRDTMLD SYENTVPQGS FLKFSMMPQR
AGNDPPGVSN ASEMEMEISN MREKFLMSVT KLVESKSYNS KVFSKEKYFQ TIKEVKEAKE
KGKKSSRDYR RAAKYDVISV QGTEKLIEAT HGERDRIRYY VHKEELFDIL HDTHLSIGHG
GRTRMLKELQ GKYGNVTKEV IVLYLTLCKQ CHQKNPVPKR GLAPKPMTFK DIDSTCQVEI
LDMQSSADGE FKFILYYQDH LTKFIILRPL RTKQAHEVVS VLLDIFTILG TPSVLDSDSG
VEFTNQVVHE LNELWPDLKI VSGKYHPGQS QGSLEEASRD VKNMISTWMQ SNHSCHWAKG
LRFMQMVRNQ AFDVSLQQSP FEAMFGCKAK FGLYSSNLPR ETVATLQTEE ELEIAEEQLE
NSLWIRQEER AEIGADRSDM DDDMDPTPEA AEPSTSQGTS SLLCW
//
