ID H2NSY1_PONAB Unreviewed; 3523 AA.
AC H2NSY1; A0A2J8RI70;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=MYO15A isoform 1 {ECO:0000313|EMBL:PNJ08216.1};
DE SubName: Full=Myosin XVA {ECO:0000313|Ensembl:ENSPPYP00000009048.2};
GN Name=MYO15A {ECO:0000313|Ensembl:ENSPPYP00000009048.2};
GN ORFNames=CR201_G0050739 {ECO:0000313|EMBL:PNJ08216.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000009048.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000009048.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ08216.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ08216.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000009048.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; NDHI03003690; PNJ08216.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000009048; -.
DR Ensembl; ENSPPYT00000009414.2; ENSPPYP00000009048.2; ENSPPYG00000008044.2.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000155335; -.
DR HOGENOM; CLU_000192_14_0_1; -.
DR OMA; YITREST; -.
DR TreeFam; TF316834; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032420; C:stereocilium; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13201; FERM_C_MyoXV; 1.
DR CDD; cd01387; MYSc_Myo15; 1.
DR CDD; cd12067; SH3_MYO15A; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041795; MyoXV_FERM_C.
DR InterPro; IPR036057; MYSc_Myo15.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF21; UNCONVENTIONAL MYOSIN-XV; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1215..1892
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 2058..2210
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 2860..2946
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 3043..3197
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 3202..3523
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1771..1793
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 2308..2374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2407..2439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2483..2503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2515..2550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2637..2657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..688
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..820
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..853
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1038
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2341..2368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2516..2530
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1308..1315
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 3523 AA; 394617 MW; D6C08998A758657B CRC64;
MAKEEDEEKK AKKGKKGKKA PEPEKPKRSL KGTSRLFMGF RDRTPKISKK GQFRSASAFF
WGLHTGPQKT KRKKKARTVL KSTSKLMTQM RMGKKKRAMK GKKPSFMVIR FPGRRGYGRL
RPRARSLSKA STAINWLTKK FLLKKAEESG SEQATVDAWL QRSSSRMGSR KLPFPSGAEI
LRPGGRLRRF PRSRSIYASG EPLGFLPFED EAPFHHSGSR KSLYGLEGFQ DLGEYYDYHR
DGDDYYDRQS LHRYEEQEPY LPGLGPYSPA WPPYGDHYYG YPPEDPYDYY HPDYYGGPFD
PGYTYGYGYG YDDYEPPYAP PSGYSSPYSY HDGYEGEAHP YGYYLDPYAP YDAPYPPYDL
PYHSPYDVPY FDPYGVPYTV PYAEGVYGGG DEAIYPPEVP YFYPEESASA FVYPWVPPPI
PSPHNPYAHA MDDIAELEEP EDAGGERQGT SFRLPSAAFF EQQGMDKPAR SKLSLIRKFR
LFPRPQVKLF GKEKLEVPLP PSLDIPLPLG DADEEEDDEE LPPVSAVPYG PPFWGFLTPR
QRNLQRALSA FGAHRGLGFG PEFGRPAPRP ATSLARFLKK TLSEKKPIAR LRGSQKARAG
GPAVREAAYK RFGYKLAGMD PEKPGTPIVL RRAQPRARSS NDARRPPAPQ PAPRTLSHWS
ALLSPPVPPR PPSPGPPPAP PLSPALSGLP RPASPYGSLR RHPPPWAAPA HVPPAPQASW
WAFVEPPAVS PEVPPDLLAF PGPRPSFRGS RRRGAAFGFP GASPRASRRR AWSPLASPQP
SLRSPPGLGY CSPLAPPSPQ LPLHTGPFQP PFPPPARSLQ ESPAPRRAAG RLGPPGSPLP
GSPRPPSPPP GLGHSPRRRS LNLPSRLPHT WRRLSEPPTR AVKPRVCPPF HRPPRSGAWR
APLEHRESPR EPEDSETPWT VPPLAPTWDV DMPATQRPPS PWPGGAGSRR GFSRPPPVRE
NPFLQLLGPV PSPTLQPEDP AADMTRVFLG RHHEPGPGQL TKSAGPTPEK PEEEATLGDP
QLPAETKPPT PTPPKDVTLP KDVLPEQKTL RPSLSYPLAA CDQTRATWPP WHRWGTLPQA
AAPLAPIRAP EPLPKRGERR QAAPGRFAVV MPRVQKLSSF QRVGPATLKP QVQPTQDPKP
RACSLRWSCL WLRADACGPW PRVHTHPQSC HLGPGAACLS LGGSWEEVGP PSWRNKMHSI
RNLPSMRFRE QHREDGVEDM TQLEDLQETT VLSNLKMRFE RNLIYTYIGS ILVSVNPYQM
FGIYGPEQVQ QYNGRALGEN PPHLFAIANL AFAKMLDAKQ NQCIIISGES GSGKTEATKL
ILRYLAAMNQ KRDVMQQIKI LEATPLLESF GNAKTVRNDN SSRFGKFIEI FLEGGVISGA
ITSQYLLEKS RIVFQAKNER NYHIFYELLA GLPAQLRQAF SLQEAETYYY LNQGGNCEIA
GKSDADDFRR LLAAMEVLGF SSEDQDSIFR ILASILHLGN VYFEKYETDA QEVASVVSAR
EIQAVAELLQ ISPEGLQKAI TFKVTETMRE KIFTPLTVES AVDARDAIAK VLYALLFSWL
ITRVNALVSP RQDTLSIAIL DIYGFEDLSF NSFEQLCINY ANENLQYLFN KIVFQEEQEE
YIREQIDWQE ITFADNQPCI NLISLKPYGI LRILDDQCCF PQATDHTFLQ KCHYHHGANP
LYSKPKMPLP EFTIKHYAGK VTYQVHKFLD KNHDQVRQDV LDLFVRSRTR VVAHLFSSHA
PQAAPQRLGK SSSVTRLYKA HTVAAKFQQS LLDLVEKMER CNPLFMRCLK PNHKKEPGLF
EPDVVMAQLR YSGVLETVRI RKEGFPVRLP FQGFIDRYCC LVALKHDLPA NGDMCVSVLS
RLCKVMPNMY RVGVSKLFLK EHLYQLLESM REHVLNLAAL TLQRCLRGFF IKRRFRSLRH
KIILLQSRAR GYLARQRYQQ MRRSLVKFRS LVHAYVSRRR YLKLRAEWRH QVEGARLWEQ
EELSKREVVA VGHLEVPAEL AGLLQAVAGL GLARVPRVAP VRTPRLQAEP RVTLPLDINN
YPMAKFVRCH FKEPAFGMLT VPLRTPLTQL PAEHHAEAVS IFKLILRFMG DPHLHGAREN
IFGNYIVQKG LAVPELRDEI LAQLANQVWH NHNAHNAERG WLLLAACLSG FAPSPRFNKY
LLKFVSDYGR NGFQAVCQHR LMQAMGRAQQ QGSGAARTLP PTQLEWTATY EKASMALDVG
CFNGDQFSCP VHSWSTGEEV AGDILRHRGL ADGWRGWTVA MKNGVQWAEL AGHDYVLDLV
SDLELLRDFP RQKSYFIVGT EGPVASRGGP KVVFGNSWDS DEDTPIRPQP QEHMPKVLDS
DGYSSHNQDG TNGETEAQRG TATHQESDSL GEPAVPHKGL DCYLDSLFDP VLSYGDADLE
KPTAIAHRMK GGGQPSGGGS SGTEDTPRRP PEPKPIPGLD ASTLALQQAF IHKQAVLLAR
EMTLQAMALQ QQPLSAALRS LPAEKPPAPE AQPKSVGTGP PAKPVLLRAT PKPLAPAPLA
KAPRPPTKPV AAPVLAQDQA SPETTSPSPE LVRYSTLNSE HFPQPTQQIK NIVRQYQQPF
RGGRPKALRK DGGKVFMKRP DPHEEALMIL KGQMTHLAAA PGTQVSREAV ALVKPVTSAP
RPSMAPTSAL PSRSLEPPEE LTQTRLHRLI NPSFYGYQDA PWRIFLRKEV FYPKDSYSHP
VQLDLLFRQI LHDTLSEACL RISEDERLRM KALFAQNQLD TQRPLVTESV KRAVVSTARD
TWEVYFSRIF PATGSVGTGV QLLAVSHVGI KLLRMVKGGQ EAGGQLRVLR AYSFADILFV
AMPSQNMLEF NLASEKVILF SARAHQVKTL VDDFILELKK DSDYVVAVRN FLPEDPALLA
FHKGDIIHLQ PLEPPRVGYS AGCVVRKKVV YLEELRRRGP DFGWRFGTIH GRVGRFPSEL
VQPAAAPDFL QLPAEPGRGR AAAVAAAVAS AAAAQEVGRR REGPPVRARS ADHGEDALAL
PPYTMLEFAQ KYFRDPQRRP QDGLRLKSKE ARESRTLEDM LCFTKTPLQE SLIELSDSSL
NKMATDMFLA VMKFMGDAPL KGQSDLDVLC NLLKLCGDHE VMRDECYCQV VKQITDNTSS
KQDSCQRGWR LLYIVTAYHS CSEVLHPHLT RFLQDMSRTP GLPFQGIAKA CEQNLQKTLR
FGGRLELPSS IELRAMLAGR SSKRQLFLLP GGLERHLKIK TCTVALDVVE EICAEMALTR
PEAFNEYVIF VVTNRGQHVC PLSRRAYILD VASEMEQVDG GYMLWFRRVL WDQPLKFENE
LYVTMHYNQV LPEYLKGLFS SVPASRPSEQ LLQQVSKLAS LQHRAKDHFY LPSMREVQEY
IPAQLYRTTA GSTWLNLVSQ HRQQTQALSP HQARAQFLGL LSALPMFGSS FFFIQSCSNI
AVPAPCILAV NHNGLNFLST ETHELMVKFP LKEIQSTRTQ RPTANSSYPY VEIALGDMAA
QRALQLQLEQ GLELCRVVAV HVENLLSAHE KRLTLPPSEI TLL
//
