ID H2NSY3_PONAB Unreviewed; 1259 AA.
AC H2NSY3; A0A2J8RI51;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=FLII actin remodeling protein {ECO:0000313|Ensembl:ENSPPYP00000009050.2};
DE SubName: Full=FLII isoform 11 {ECO:0000313|EMBL:PNJ08203.1};
GN Name=FLII {ECO:0000313|Ensembl:ENSPPYP00000009050.2};
GN ORFNames=CR201_G0050735 {ECO:0000313|EMBL:PNJ08203.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000009050.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000009050.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ08203.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ08203.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000009050.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003690; PNJ08203.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000009417.2; ENSPPYP00000009050.2; ENSPPYG00000008047.2.
DR GeneTree; ENSGT00940000156643; -.
DR HOGENOM; CLU_002568_1_0_1; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR CDD; cd11280; gelsolin_like; 2.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.20.10; Severin; 6.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977:SF139; PROTEIN FLIGHTLESS-1 HOMOLOG; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 5.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00597; GELSOLIN.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 6.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 498..580
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 618..692
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 747..820
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 1065..1133
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 1171..1244
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 403..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 143836 MW; C0A101E11AEDD8D5 CRC64;
MDLRGLRPVP GGYFPENVKA MTSLRWLKLN RTGLCYLPEE LAALQKLEHL SVSHNNLTTL
HGELSSLPSL RAIVARANSL KNSGVPDDIF KLDDLSVLDL SHNQLTECPR ELENAKNMLV
LNLSHNSIDT IPNQLFINLT DLLYLDLSEN RLESLPPQMR RLVHLQTLVL NGNPLLHAQL
RQLPAMTALQ TLHLRSTQRT QSNLPTSLEG LSNLADVDLS CNDLTRVPEC LYTLPSLRRL
NLSSNQITEL SLCIDQWVHV ETLNLSRNQL TSLPSAICKL SKLKKLYLNS NKLDFDGLPS
GIGKLTNLEE FMAANNNLEL IPESLCRCPK LRKLVVNKNR LVTLPEAIHF LTEIEVLDVR
ENPNLVMPPK PADRAAEWYN IDFSLQNQLR LAGASPATVA AAAAAGSGPK DPMARKMRLR
RRKDSAQDDQ AKQVLKGMSD VAQEKNKKQE ENADARAPGG KVRRWDQGLE KPRLDYSEFF
TEDVGQLPGL TIWQIENFVP VLVEEAFHGK FYEADCYIVL KTFLDDSGSL NWEIYYWIGG
EATLDKKACS AIHAVNLRNY LGAECRTVRE EMGDESEEFL QVFDNDISYI EGGTASGFYT
VEDTHYVTRM YRVYGKKNIK LEPVPLKGTS LDPRFVFLLD RGLDIYVWRG AQATLSSTTK
ARLFAEKINK NERKGKAEIT LLVQGQELPE FWEAMGGEPS EIKKHVPDDF WPPQPKLYKV
GLGLGYLELP QINYKLSVEH KQRPKVELMP RMRLLQSLLD TRCVYILDCW SDVFIWLGRK
SPRLVRAAAL KLGQELCGML HRPRHATVSR SLEGTEAQVF KAKFKNWDDV LTVDYTRNAE
AVLQSPGLSG KVKRDAEKKD QMKADLTALF LPRQPPMSLA EAEQLMEEWN EDLDGMEGFV
LEGKKFARLP EEEFGHFYTQ DCYVFLCRYW VPVEYEEEEK KEDKEEEKAE GKEGEEATAE
AEEKQPEEDF QCIVYFWQGR EASNMGWLTF TFSLQKKFES LFPGKLEVVR MTQQQENPKF
LSHFKRKFII HRGKRKAVQG AQQPSLYQIR TNGSALCTRC IQINTDSSLL NSEFCFILKV
PFESEDNQGI VYAWVGRASD PDEAKLAEDI LNTMFDTSYS KQVINEGEEP ENFFWVGIGA
QKPYDDDAEY MKHTRLFRCS NEKGYFAVTE KCSDFCQDDL ADDDIMLLDN GQEVYMWVGT
QTSQVEIKLS LKACQVYIQH IRSKEHERPR RLRLVRKGNE QHAFTRCFHA WSAFRKALA
//
