ID H2NTQ8_PONAB Unreviewed; 549 AA.
AC H2NTQ8; A0A2J8UYW9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=ARHGAP27 isoform 4 {ECO:0000313|EMBL:PNJ50467.1};
DE SubName: Full=Rho GTPase activating protein 27 {ECO:0000313|Ensembl:ENSPPYP00000009332.3};
GN Name=ARHGAP27 {ECO:0000313|Ensembl:ENSPPYP00000009332.3};
GN ORFNames=CR201_G0023760 {ECO:0000313|EMBL:PNJ50467.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000009332.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000009332.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ50467.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ50467.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000009332.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003438; PNJ50467.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000009709.3; ENSPPYP00000009332.3; ENSPPYG00000008305.3.
DR eggNOG; KOG1449; Eukaryota.
DR eggNOG; KOG1450; Eukaryota.
DR GeneTree; ENSGT00950000182860; -.
DR HOGENOM; CLU_015883_6_2_1; -.
DR TreeFam; TF329345; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR23176:SF104; RHO GTPASE-ACTIVATING PROTEIN 27; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 76..103
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 155..271
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 357..546
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 61806 MW; 90EA7F74CB67C32D CRC64;
MQPGLSPGSP GDPRPPTPET DYPESLTSYP EEDYSPVGSF GEPGPTSPLT TPPGWSCHVS
QDKQMLYTNH FTQEQWVRLE DPHGKPYFYN PEDSSVRWEL PQVPVPAPRS IHKASQDGDT
PAQASPPEEK VPAELDEVGS WEEVSPATAA VRTKTLDKAG VLHRTKTADK GKRLRKKHWS
ASWTVLEGGV LTFFKDSKTS AAGGLRQPSK FSTPEYTVEL RGAILSWAPK DKSSRKNVLE
LRSRDGSEYL IQHDSEAIIS TWHKAIAQGI QELSAELPPE EESESSRADF GSSERLGSWQ
EKEEDARPNA ATPALSPGGL ESDVSKVRHK LRKFLQRRPT LQSLREKGYI KDQVFGCALA
ALCERERSRV PRFVQQCIRA VEARGLDIDG LYRISGNLAT IQKLRYKVDH DERLDLDDGR
WEDVHVITGA LKLFFRELPE PLFPFSHFRQ FIAAIKLQDQ AQRSRCVRDL VRSLPAPNHD
TLRMLFQHLC RVIEHGEQNR MSVQSVAIVF GPTLLRPEVE ETSMPMTMVF QNQVVELILQ
QCADIFPPH
//
