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Database: UniProt
Entry: H2NU10_PONAB
LinkDB: H2NU10_PONAB
Original site: H2NU10_PONAB 
ID   H2NU10_PONAB            Unreviewed;       788 AA.
AC   H2NU10;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   31-JUL-2019, entry version 49.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=STAT5B {ECO:0000313|Ensembl:ENSPPYP00000009440};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000009440, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000009440, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000009440}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   EMBL; ABGA01303307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01303316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002827565.1; XM_002827519.2.
DR   STRING; 9601.ENSPPYP00000009440; -.
DR   Ensembl; ENSPPYT00000009819; ENSPPYP00000009440; ENSPPYG00000008394.
DR   GeneID; 100462537; -.
DR   KEGG; pon:100462537; -.
DR   CTD; 6777; -.
DR   eggNOG; KOG3667; Eukaryota.
DR   eggNOG; ENOG410XPN8; LUCA.
DR   GeneTree; ENSGT00950000182688; -.
DR   InParanoid; H2NU10; -.
DR   KO; K11224; -.
DR   OMA; TIWQNRQ; -.
DR   OrthoDB; 327469at2759; -.
DR   TreeFam; TF318648; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0035259; F:glucocorticoid receptor binding; IEA:Ensembl.
DR   GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   CDD; cd10420; SH2_STAT5b; 1.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR035858; STAT5a/5b.
DR   InterPro; IPR035886; STAT5b_SH2.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 1.
DR   PANTHER; PTHR11801:SF47; PTHR11801:SF47; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      589    686       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED      148    168       {ECO:0000256|SAM:Coils}.
FT   COILED      215    235       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   788 AA;  90032 MW;  6DBDFFF785DFA92D CRC64;
     MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL
     LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV
     REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL
     RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL
     RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
     QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
     NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS
     LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA
     TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN
     SSSHLEDYSG LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK
     QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL
     GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV KPQIKQVVPE FVNASADAGG
     GSATYMDQAP LPKLCAPRLT INMYPQNPDS VLDTDGDFDL EDTMDVARRV EELLGRPMDS
     QWIPHAQS
//
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