ID   H2NU46_PONAB            Unreviewed;       174 AA.
AC   H2NU46;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000009477.2};
GN   Name=LOC100447272 {ECO:0000313|Ensembl:ENSPPYP00000009477.2};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000009477.2, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000009477.2, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000009477.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins. {ECO:0000256|ARBA:ARBA00003327}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000256|ARBA:ARBA00011662}.
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DR   AlphaFoldDB; H2NU46; -.
DR   Ensembl; ENSPPYT00000009858.2; ENSPPYP00000009477.2; ENSPPYG00000031008.1.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00940000156135; -.
DR   HOGENOM; CLU_113141_0_0_1; -.
DR   InParanoid; H2NU46; -.
DR   OMA; CCATRCV; -.
DR   TreeFam; TF351356; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; KERATIN ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR23262:SF183; KERATIN-ASSOCIATED PROTEIN 4-11-RELATED; 1.
DR   Pfam; PF13885; Keratin_B2_2; 3.
PE   4: Predicted;
KW   Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ   SEQUENCE   174 AA;  18375 MW;  A66B182E016A1F76 CRC64;
     MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP SCCVSSCCQP CCHPTCCQNT
     CCRTTCCQPT CVTSCCQPSC CSTSCCQPTC CGSSCCGQTS CGSSYGQSSS CAPVYCRRTC
     YHPTTVCLPG CFNQSCGSSC CQPCCRPACC ETTCCRTTCF QPTCVSSCCQ PFCC
//