ID H2NWJ0_PONAB Unreviewed; 772 AA.
AC H2NWJ0; A0A2J8W3P1; A0A6D2WSH1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=CDH19 isoform 1 {ECO:0000313|EMBL:PNJ64395.1};
DE SubName: Full=Cadherin 19 {ECO:0000313|Ensembl:ENSPPYP00000010354.2};
GN Name=CDH19 {ECO:0000313|Ensembl:ENSPPYP00000010354.2};
GN ORFNames=CR201_G0013555 {ECO:0000313|EMBL:PNJ64395.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000010354.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000010354.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ64395.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ64395.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000010354.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; NDHI03003401; PNJ64395.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000010354; -.
DR Ensembl; ENSPPYT00000010766.3; ENSPPYP00000010354.2; ENSPPYG00000009227.3.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000160137; -.
DR HOGENOM; CLU_005284_3_1_1; -.
DR OMA; TIYVCDC; -.
DR OrthoDB; 3667774at2759; -.
DR TreeFam; TF329887; -.
DR Proteomes; UP000001595; Chromosome 18.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF323; CADHERIN-19; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..772
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014574866"
FT TRANSMEM 597..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..148
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 149..256
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 257..370
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 371..470
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 470..581
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 772 AA; 87280 MW; 21CAAD7F96945D8B CRC64;
MNCYLLLRFM LGIPLLWPCL GATENSQTKK VEQPVRSHLR VKRGWMWNQF FVPEEMNTTS
HHIGRLRSDL DNGNNSFQYK LLGAGAGSTF IIDERTGDIY ARQKLDREER SLYTLRAQVI
DITTGRAVEP DSEFVIKVSD INDNEPKFLD EPYEAIVPEM SPEGTLVIQV TASDADDPSS
GNNARLLYSL LQGQPYFSVE PTTGVIRISS KMDRELQDEY WVIIQAKDMI GQPGALSGTT
SVLIKLSDVN DNKPIFKESL YRLTVSESAP TGTSIGTIMA YDNDIGENAE MDYSIEEDDS
QTFDIITNRE TQEGIVILKK KVDFEYQNHY GIRAKVKNHH VDEHLMKYHT EPSTTFIKIQ
VEDVDEPPLF LLPYYIFEIF EETPQGSFVG VVSATDPDNR KSPIRYSITR SKVFNIDDNG
TITTTNSLDR EISAWYNLSI TATEKYNIEQ ISSIPVYVQV LNINDHAPEF SQYYETYVCE
NAGSGQVIQT ISAVDRDESI EEHHFYFNLS VEDTNNSSFA IIDNQDNTAV ILTNRTAFNL
QEEPVFYISI LIADNGIPSL TSTNTLTIHV CDCGDSGSTQ TCQYQELVLS MGFKTEVIIA
ILICIMIIFG FIFLTLGLKQ RRKQILFPEK SEDFRENIFR YDDEGGGEED TEAFDIAELR
SSTIMRERKT RKTTSTEIRS LYRQSLQVGP DSAIFRKFIL EKLEEANTDP CAPPFDSLQT
YAFEGTGSLA GSLSSLESAV SDQDESYDYL NELGPRFKRL ACMFGSAVQS NN
//
