ID H2NYQ9_PONAB Unreviewed; 704 AA.
AC H2NYQ9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=serine--tRNA ligase {ECO:0000256|ARBA:ARBA00012840};
DE EC=6.1.1.11 {ECO:0000256|ARBA:ARBA00012840};
DE AltName: Full=Seryl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031113};
DE AltName: Full=Seryl-tRNA(Ser/Sec) synthetase {ECO:0000256|ARBA:ARBA00033352};
GN Name=SARS2 {ECO:0000313|Ensembl:ENSPPYP00000011141.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011141.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011141.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000011141.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-
CC seryl-tRNA(Sec); Xref=Rhea:RHEA:42580, Rhea:RHEA-COMP:9742,
CC Rhea:RHEA-COMP:10128, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:33384, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78533, ChEBI:CHEBI:456215; EC=6.1.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00001032};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-
CC seryl-tRNA(Ser); Xref=Rhea:RHEA:12292, Rhea:RHEA-COMP:9669,
CC Rhea:RHEA-COMP:9703, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:33384, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78533, ChEBI:CHEBI:456215; EC=6.1.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00001706};
CC -!- PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec)
CC biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005045}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Type-1 seryl-tRNA synthetase subfamily.
CC {ECO:0000256|ARBA:ARBA00010728}.
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DR AlphaFoldDB; H2NYQ9; -.
DR Ensembl; ENSPPYT00000011576.3; ENSPPYP00000011141.3; ENSPPYG00000009949.3.
DR eggNOG; ENOG502RZA6; Eukaryota.
DR GeneTree; ENSGT00940000153792; -.
DR HOGENOM; CLU_068548_0_0_1; -.
DR InParanoid; H2NYQ9; -.
DR OrthoDB; 587001at2759; -.
DR TreeFam; TF320527; -.
DR UniPathway; UPA00906; UER00895.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004828; F:serine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0006434; P:seryl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd22169; F-box_FBXO17-like; 1.
DR CDD; cd00770; SerRS_core; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR002314; aa-tRNA-synt_IIb.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR007397; F-box-assoc_dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002317; Ser-tRNA-ligase_type_1.
DR InterPro; IPR033729; SerRS_core.
DR InterPro; IPR010978; tRNA-bd_arm.
DR NCBIfam; TIGR00414; serS; 1.
DR PANTHER; PTHR11778:SF7; SERINE--TRNA LIGASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR11778; SERYL-TRNA SYNTHETASE; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF04300; FBA; 1.
DR Pfam; PF00587; tRNA-synt_2b; 1.
DR PRINTS; PR00981; TRNASYNTHSER.
DR SMART; SM01198; FBA; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF46589; tRNA-binding arm; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
DR PROSITE; PS51114; FBA; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 15..62
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT DOMAIN 99..275
FT /note="FBA"
FT /evidence="ECO:0000259|PROSITE:PS51114"
FT DOMAIN 367..643
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
FT REGION 667..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 261..288
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 704 AA; 79252 MW; B6A89240B9414A05 CRC64;
MGARLSRRRL PADPSLTLDA LPPELLVQLL SHVPPRALVT RCRPVCRAWR DIVDGPTVWL
LQLARDRSAE GRALYAVAQR CLPSKEDKEE FPLCALARYC LRAPFGRNLI FNSCGEQGFR
GWEVEHGGNG WAIEKNLTPV PGAPSQTCFV TSFEWCSKRQ LVDLVMEGVW QELLDSAQIE
ICVADWWGAR ENCGCVYQLR VRLLDVYEKE VVKFSASPDP VLQWTERGCR QVSHVFTNFG
KGIRYVSFEQ YGRDISTWQE LRQLREQIRS LEEEKAAVTE GVRALLANQD SGEVQQDPKY
QGLRARGREI RKELVHLYPR EAQLEEQFYL QALKLPNQTH PDVPVGDESQ ARVLHVVGDK
PVFSFRPRGH LEIGEKLDII RQKRLSHVSG HRSYYLRGAG ALLQHGLVNF TFNKLLHRGF
TPMTVPDLLR GAVFEGCGMT PNANPSQIYN IDPARFKDLN LAGTAEVGLA GYFMDHAVAF
RDLPVRMVCS STCYRAETNT GQEPWGLYRV HHFTKVEMFG VTGPGLEQSS QLLEEFLSLQ
MEILTELGLH FRVLDMPTQE LGLPTYRKFD IEAWMPGRGH FGEVTSASNC TDFQSRRLHI
MFQTETGELQ FAHTVNATAC AVPRLLIALL ESNQQKDGSV LVPPALQPYL GTDRITATTH
VPLQYIGPNQ PRKPGLPGQP ALHARAPGPR GPPLLCPCCL RVSH
//
