ID H2NZM1_PONAB Unreviewed; 1069 AA.
AC H2NZM1; A0A2J8U7Z7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=TRPM4 isoform 6 {ECO:0000313|EMBL:PNJ41383.1};
DE SubName: Full=Transient receptor potential cation channel subfamily M member 4 {ECO:0000313|Ensembl:ENSPPYP00000011464.3};
GN Name=TRPM4 {ECO:0000313|Ensembl:ENSPPYP00000011464.3};
GN ORFNames=CR201_G0029615 {ECO:0000313|EMBL:PNJ41383.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011464.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011464.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ41383.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ41383.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000011464.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; NDHI03003467; PNJ41383.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000011464; -.
DR Ensembl; ENSPPYT00000011906.3; ENSPPYP00000011464.3; ENSPPYG00000010239.3.
DR eggNOG; KOG3614; Eukaryota.
DR GeneTree; ENSGT00940000158693; -.
DR HOGENOM; CLU_001390_0_1_1; -.
DR TreeFam; TF314204; -.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR SUPFAM; SSF140860; Pseudo ankyrin repeat-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 690..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 785..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..318
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 757..906
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT COILED 989..1040
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1069 AA; 118674 MW; 74999E27E24404CB CRC64;
MVVPEKEQSW IPKIFKKKTC TTFIVDSTDP GGTLCQCGRP RTAHPAVAME DAFGAAVVTV
WDSDTHTTEK PTDAYGELDF MGAGRKHSNF LRLSDRTDPA TVYSLVTRTW GFRAPNLVVS
VLGGSGGPVL QTWLQDLLRR GLVRAAQSTG AWIVAGGLHT GIGRHVGVAV RDHQTASTGG
TKVVAMGVAP WGVVRNRDTL TNPKGSFPAR YRWRGDPEDG VQFPLDYNYS AFFLVDDGTH
GCLGGENRFR LRLESYISQQ KTGVGGTGID IPVLLLLIDG DEKMLTRIEN ATQAQLPCLL
VAGSGGAADC LAETLEDTLA PGSGVARQGE ARDRIRRFFP KGDLEVLQAQ VERIMTRKEL
LTVYSSEDGS EEFETIVLKA LVKACGSSEA SAYLDELRLA VAWNRVDIAQ SELFRGDIQW
RSFHLEASLM DALLNDRPEF VRLLISHGLS LGHFLTPMRL AQLYSAAPPN SLIRNLLDQA
SHSAGTKAPA LKGGAAEPRP PDVGHVLRML LGKMCAPRYP SGGAWDPHPG QGFGESMCLL
SDKATSLLSL DAGLGQAPWS DLLLWALLLN RAQMAMYFWE MGSNAVSSAL GACLLLRVMA
RLEPDAEEAA RRKDLAFKFE GMGVDLFGEC YRSSEVRAAR LLLRRCPLWG DATCLQLAMQ
ADARAFFAQD GVQSLLTQKW WGDMASTTPI WALVLAFFCP PLIYTRLITF RKSEEEPTRE
ELEFDMDSVI NGEGPVGLTP GLYHLGRTVL CIDFMVFTVR LLHIFTVNKQ LGPKIVIVSK
MMKDVFFFLF FLGVWLVAYG VATEGLLRPR DSDFPSILRR VFYRPYLQIF GQIPQEDMDV
ALMEHSNCSS EPGFWAHPPG AQAGTCVSQY ANWLVVLLLV IFLLVANILL VNLLIAMFSY
TFGKVQGNSD LYWKSQRYRL IREFHSRPAL APPFIVISHM RLLLRQLCRR PRSPQPSSPA
LEHFRVYLSK EAERKLLTWE SVHKENFLLA RARDKRESDS ERLKRTSQKV DLALKQLGHI
REYEQRLKVL EREVQQCSRV LGWVAEALSR SALLPPGGPP PPDLPGSKD
//
