ID H2P068_PONAB Unreviewed; 226 AA.
AC H2P068;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Lysoplasmalogenase TMEM86B {ECO:0000256|ARBA:ARBA00039876};
DE EC=3.3.2.2 {ECO:0000256|ARBA:ARBA00035673};
DE AltName: Full=Transmembrane protein 86B {ECO:0000256|ARBA:ARBA00042674};
GN Name=TMEM86B {ECO:0000313|Ensembl:ENSPPYP00000011665.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011665.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011665.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000011665.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline
CC or ethanolamine lysoplasmalogens, forming fatty aldehyde and
CC glycerophosphocholine or glycerophosphoethanolamine, respectively and
CC is specific for the sn-2-deacylated (lyso) form of plasmalogen.
CC {ECO:0000256|ARBA:ARBA00037660}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-
CC saturated aldehyde + sn-glycerol 3-phosphocholine;
CC Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00035598};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a
CC 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine;
CC Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359,
CC ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00035579};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM86 family.
CC {ECO:0000256|ARBA:ARBA00007375}.
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DR RefSeq; XP_002829820.1; XM_002829774.2.
DR AlphaFoldDB; H2P068; -.
DR Ensembl; ENSPPYT00000012109.2; ENSPPYP00000011665.1; ENSPPYG00000010406.2.
DR GeneID; 100448045; -.
DR KEGG; pon:100448045; -.
DR CTD; 255043; -.
DR eggNOG; KOG4804; Eukaryota.
DR GeneTree; ENSGT00390000007101; -.
DR HOGENOM; CLU_079086_1_0_1; -.
DR InParanoid; H2P068; -.
DR OMA; WPETFLH; -.
DR OrthoDB; 3030862at2759; -.
DR TreeFam; TF324663; -.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047408; F:alkenylglycerophosphocholine hydrolase activity; IEA:Ensembl.
DR GO; GO:0047409; F:alkenylglycerophosphoethanolamine hydrolase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046485; P:ether lipid metabolic process; IEA:Ensembl.
DR InterPro; IPR012506; TMEM86B-like.
DR PANTHER; PTHR31885; GH04784P; 1.
DR PANTHER; PTHR31885:SF7; LYSOPLASMALOGENASE; 1.
DR Pfam; PF07947; YhhN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 226 AA; 24497 MW; 3C53A9E1390B90F4 CRC64;
MDASKAGQTL KIHCSAQRPD VCRWLSPFIL SCCVYFCLWI PEDQLSWFAA LIKCLPVLCL
AGFLWIMSPS GGYTRLLQGA LVCSAVGDAC LIWPEAFLPG MAAFATAHLL YVWAFGFSPL
QPGLLLLIIL ASGPYLSLVL QHLEPDMVLP VAAYGLILMA VLWRGLARGG SAGWGVLLFT
LSDGMLAWDT FAQPLPHARL VIMATYCAAQ LLITLSALRS PVPKTD
//
