ID H2P126_PONAB Unreviewed; 425 AA.
AC H2P126; A0A2J8VD64; A0A663DBL9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=MACROD2 isoform 1 {ECO:0000313|EMBL:PNJ55456.1};
DE SubName: Full=Mono-ADP ribosylhydrolase 2 {ECO:0000313|Ensembl:ENSPPYP00000011983.2};
GN Name=MACROD2 {ECO:0000313|Ensembl:ENSPPYP00000011983.2};
GN ORFNames=CR201_G0019693 {ECO:0000313|EMBL:PNJ55456.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000011983.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000011983.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ55456.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ55456.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000011983.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; NDHI03003422; PNJ55456.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000011983; -.
DR Ensembl; ENSPPYT00000012454.3; ENSPPYP00000011983.2; ENSPPYG00000010718.3.
DR eggNOG; KOG2633; Eukaryota.
DR GeneTree; ENSGT00940000157404; -.
DR HOGENOM; CLU_046550_10_3_1; -.
DR TreeFam; TF341440; -.
DR Proteomes; UP000001595; Chromosome 20.
DR CDD; cd02908; Macro_OAADPr_deacetylase; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR PANTHER; PTHR11106:SF27; ADP-RIBOSE GLYCOHYDROLASE MACROD2; 1.
DR PANTHER; PTHR11106; GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED; 1.
DR Pfam; PF01661; Macro; 1.
DR SMART; SM00506; A1pp; 1.
DR SUPFAM; SSF52949; Macro domain-like; 1.
DR PROSITE; PS51154; MACRO; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 59..240
FT /note="Macro"
FT /evidence="ECO:0000259|PROSITE:PS51154"
FT REGION 243..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..258
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 425 AA; 47274 MW; BB800E22D24C69B8 CRC64;
MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
AFPCISTGIY GFPNEPAAVI ALSTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEGQSQDAD GVNTVTVPGP ASEEAVEDCK
DEDSAKDDNI TKGSEETDHS VCDQDHPDGQ ENDSMKNEIK IETESQSSYM ETEELSSNQE
DAVIVEQPEV IPLTDDQEEK ESEKAPGEDT PTVPGKSEGF SDLENTPGPD AGAQDEAKEQ
RNGTK
//
