ID H2P1F5_PONAB Unreviewed; 507 AA.
AC H2P1F5; A0A2J8VI48;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=SIRPA isoform 1 {ECO:0000313|EMBL:PNJ57202.1};
DE SubName: Full=Signal regulatory protein alpha {ECO:0000313|Ensembl:ENSPPYP00000012114.3};
GN ORFNames=CR201_G0018429 {ECO:0000313|EMBL:PNJ57202.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000012114.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000012114.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ57202.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ57202.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000012114.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; NDHI03003419; PNJ57202.1; -; Genomic_DNA.
DR Ensembl; ENSPPYT00000012592.3; ENSPPYP00000012114.3; ENSPPYG00000029662.2.
DR eggNOG; ENOG502S1XD; Eukaryota.
DR GeneTree; ENSGT00960000186656; -.
DR HOGENOM; CLU_044430_2_0_1; -.
DR OMA; EVICEVN; -.
DR OrthoDB; 5401342at2759; -.
DR TreeFam; TF341862; -.
DR Proteomes; UP000001595; Chromosome 20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05772; IgC1_SIRP_domain_2; 1.
DR CDD; cd16085; IgC1_SIRP_domain_3; 1.
DR CDD; cd16097; IgV_SIRP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR19971; SIGNAL-REGULATORY PROTEIN BETA; 1.
DR PANTHER; PTHR19971:SF35; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1; 1.
DR Pfam; PF07654; C1-set; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00407; IGc1; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..507
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040103234"
FT TRANSMEM 371..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 147..246
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 253..341
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 401..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 55745 MW; 97931584583F693F CRC64;
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPE KSVSVAAGES ATLHCTVTSL
NPVGPIQWFR GAGPDRELIY HQKEGHFPRV TTISDLTKRN NMDFSIRISN ITPEDAGTYY
CVKFRKGSPD MEFKSGAGTE LSVRAKPSAP VVSGPTARAT PEHTVNFTCE SHGFSPRDIT
LKWFKNGNQL SDFQTNVDPI GESVSYSIHS TAKVVLTRED VHSQVICEVA HVTLQGDPLR
GTANLSETIR VPPTLEVTQQ PMRAENQVNV TCQVRKFYPQ RLQLTWLENG NVSRTETAST
LTENKDGTYN WMSWLLVNVS AHRDDVKLTC QVEHDGQPAV SKNYDLKVSA HPKEQGSNTA
AENTGPNERN VYIVVGVVCT LLVALLMAAL YLVRIRQKKA QGSTSSTRLH EPEKNAREIT
QVQSLDTNDI TYADLNLPKE KKPAPRAAEP NNHTEYASIQ TSPQPASEDT LTYADLDMVH
LNRTPKQPAP KPEPSFSEYA SVQVPRK
//