ID H2P3D7_PONAB Unreviewed; 380 AA.
AC H2P3D7; A0A2J8RS98;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=KRTAP10-7 isoform 1 {ECO:0000313|EMBL:PNJ11400.1};
DE SubName: Full=Keratin associated protein 10-7 {ECO:0000313|Ensembl:ENSPPYP00000012831.2};
GN Name=KRTAP10-7 {ECO:0000313|Ensembl:ENSPPYP00000012831.2};
GN ORFNames=CR201_G0048979 {ECO:0000313|EMBL:PNJ11400.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000012831.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000012831.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ11400.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ11400.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000012831.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000256|ARBA:ARBA00003327}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000256|ARBA:ARBA00011662}.
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DR EMBL; NDHI03003657; PNJ11400.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000012831; -.
DR Ensembl; ENSPPYT00000013348.2; ENSPPYP00000012831.2; ENSPPYG00000011493.2.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000163845; -.
DR HOGENOM; CLU_062832_0_0_1; -.
DR OMA; CCPPKCP; -.
DR OrthoDB; 5267189at2759; -.
DR Proteomes; UP000001595; Chromosome 21.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; KERATIN ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23262:SF233; KERATIN-ASSOCIATED PROTEIN 10-12; 1.
DR Pfam; PF13885; Keratin_B2_2; 3.
PE 4: Predicted;
KW Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 380 AA; 38479 MW; AFEB3C808E54DBA9 CRC64;
MAASTMSICS SDLSYSSRVC LPGSCDTCSD SWQVDDCPES CCEPPCCAPS CCAPAPCLTL
VCTPVSCVSS PCCQVTCEPS PCQSGCTSSC TPSCCQQSSC QPACCASSPC QQSCCVPVYC
KTVCCKPVCC VPICSGASSC CQQSSCQPAC CTSSPCQQAC CVPVCCKPVC SGISSSCCQQ
SSCVSCVSSP CCQAVCEPSP CQSGCTSSCT PSCCQQSSCQ PACCTSSPCQ QSCCMPVCCK
PVCYAPTCSD DSCSCCQQSS CQPACCTSSQ SQQGCCVPVC CKPVCCVPVC SGASTSCCQQ
SSCQPACYTT SCCRPSSSVS LLCRPVCRPA CCVPVSSCCA PTSSCQATCC RPASCVSLLC
RPASSRPACC GPTSTQKSSC
//
