GenomeNet

Database: UniProt
Entry: H2P3G5_PONAB
LinkDB: H2P3G5_PONAB
Original site: H2P3G5_PONAB 
ID   H2P3G5_PONAB            Unreviewed;      1749 AA.
AC   H2P3G5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=FZ domain-containing protein {ECO:0000259|PROSITE:PS50038};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000012859.2, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000012859.2, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000012859.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Ensembl; ENSPPYT00000013379.2; ENSPPYP00000012859.2; ENSPPYG00000011521.3.
DR   eggNOG; KOG3546; Eukaryota.
DR   eggNOG; KOG3577; Eukaryota.
DR   GeneTree; ENSGT00940000158212; -.
DR   HOGENOM; CLU_004003_1_0_1; -.
DR   InParanoid; H2P3G5; -.
DR   OMA; QDQHQNI; -.
DR   TreeFam; TF315821; -.
DR   Proteomes; UP000001595; Chromosome 21.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProt.
DR   CDD; cd07455; CRD_Collagen_XVIII; 1.
DR   CDD; cd00247; Endostatin-like; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 3.40.1620.70; -; 1.
DR   Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR035523; Collagen_XVIII_Fz.
DR   InterPro; IPR010515; Collagenase_NC10/endostatin.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR010363; DUF959_COL18_N.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR048287; TSPN-like_N.
DR   InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR   PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR   PANTHER; PTHR24023:SF1034; COLLAGEN ALPHA-1(XVIII) CHAIN; 1.
DR   Pfam; PF01391; Collagen; 4.
DR   Pfam; PF20010; Collagen_trimer; 1.
DR   Pfam; PF06121; DUF959; 1.
DR   Pfam; PF06482; Endostatin; 1.
DR   Pfam; PF01392; Fz; 1.
DR   SMART; SM00063; FRI; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR   PROSITE; PS50038; FZ; 1.
PE   4: Predicted;
KW   Collagen {ECO:0000256|ARBA:ARBA00023119};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00090}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1749
FT                   /note="FZ domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035317234"
FT   DOMAIN          324..441
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   REGION          42..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          640..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          678..1437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1506..1550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..203
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        711..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        759..808
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        856..870
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        898..912
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        933..957
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        999..1017
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1248..1264
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1315..1332
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1347..1363
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1370..1432
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1511..1525
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        339..385
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT   DISULFID        376..414
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ   SEQUENCE   1749 AA;  178144 MW;  1A8A03C68DBB3BFA CRC64;
     MAPDPRGCRI LLLLFCSLAA ARADLLNLNW LWFNNEDTSH AATTIPEPQG PLPAQPTHMA
     PRNGSTEPAT VPGSPEPPSE LLEDGQDTPT SAESPDTPEE NIAGVGAKIL NVAQGIRSFV
     QLWNDTVPTE SLTRAETLVL ETPVGPFALP GPSSTPQENG TTLWPSRGTP SSPGAHTTEA
     GTLPAPTPSP PSLGRPWAPL TGPSVPPSSS GRASLSSLLG GAPPWGSLQD PDSQGLSPAA
     AAASQQLQHP DVRLRTPLLH PLVTGSLGKH AAPSAFSSGL PGALSQVAIT TLIGDSGAWV
     SHAANSAGPG LANNSALLRA DPEAPAGRCL PLPPSLPVCG RLGISRSWLP NHLHHESGEQ
     VRAGAQAWGG LLRTRCHPFL AWFFCLLLAP PCGSVPPPTP PPCRQFCEAL QDACWSRLGG
     GRLPVACASL PTQEDGYCVF IGPAAERVSE EVGLLQLLGD PPPQQVTQTD DPDVGLAYVF
     GPDANSGQVA RYHFPSLFFR DFSLLFHIRP ATEGPGVLFA ITDSAQAVVL LGVKLSGVQD
     GHQDISLLYT EPGAGQTHTA ASFRLPAFVG QWTHLALSVE GGYVTLYVDC EEFQRMLLAR
     SSRGLELEPG AGLFVAQAGG ADPDKFQGMI AELKVRGDPQ VSPMHCLDEE GDDSDGASGD
     FGSGLGDARE LLREETGAAL KPRLPMPPPV TTPPLAGGSS TEDSRSKEIE EQTTVASLGG
     QTLPGSDSVS TWDGSVRTPG DRVREGGLKG QKGEPGVPGP PGRAGPPGSP CLPGPPGLPC
     PVSPLGPAGP ALQPVPGPQG PPGPPGRDGT PGRDGEPGDP GEDGKPGDTG PQGFPGTPGD
     VGPKGDKGDP GVGERGPPGP QGPPGPPGPS FRHDKLTFID MEGSGFGGDL EALRGPRGFP
     GPPGPPGVPG LPGEPGLFGV NSSDVPGPAG LPGVPGREGP PGFPGLPGPP GPPGREGPPG
     RTGQKGSLGE AGAPGHKGSK GDPGPAGARG ESGLAGSPGP AGPPGPPGPP GPPGPGLPAG
     FDDMEGSGGP FWSTARSADG PQGPPGLPGL KGDPGMPGLP GAKGEVGADG APGFPGLPGR
     EGIAGPQGPK GDRGSQGEKG DPGKDGVGQP GLPGPPGPPG PVVYVSEQDG SVLSVPGPEG
     RPGFAGFPGP AGPKGDLGSK GERGSPGPKG EKGEPGSIFR PDGGALGPVQ KGAKGEPGFR
     GPPGPYGRPG YKGEIGFPGR PGRPGMNGLK GEKGEPGDAS LGFGMRGMPG PPGPPGPPGP
     PGTPVYDSNV FAESSRPGPP GLPGNQGPPG PKGAKGEVGP PGPPGQFPFD FLQLEAEMKG
     EKGDRGDAGQ KGERGEPGGG GFFGSRLPGP PGPPGPPGYP GIPGPKGESI RGQPGPPGPQ
     GPPGIGYEGR QGPPGPPGPP GPPGPPSFPG PHRQTISVPG PPGPPGPPGP PGTVGASSGV
     RLWATRQAML GQVHEVPEGW LIFVAEQEEL YVRVRNGFRK VQLEARTPLP RGTDNEVAAL
     QPPVVQLHDS NPYPRREHPH PTARPWRADD ILASPPRLPE PQPYPGAPHH SSYVHLRPAR
     PTSPPAHTHR DFQPVLHLVA LNSPLSGSMR GIRGADFQCF QQARAVGLAG TFRAFLSSRL
     QDLYSIVRRA DRAAVPIVNL KDELLFPSWE ALFSGSEGPL KPGARIFSFD GKDVLRHPTW
     PQKSVWHGSD PNGRRLTESY CETWRTEAPS ATGQASSLLG GRLLGQNAAS CHHAYIVLCI
     ENSFMTASK
//
DBGET integrated database retrieval system