ID H2P4J4_PONAB Unreviewed; 344 AA.
AC H2P4J4; A0A2J8TWR4; A0A663DAA6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=TOB2 isoform 1 {ECO:0000313|EMBL:PNJ37466.1};
DE SubName: Full=Transducer of ERBB2, 2 {ECO:0000313|Ensembl:ENSPPYP00000013246.1};
GN Name=TOB2 {ECO:0000313|Ensembl:ENSPPYP00000013246.1};
GN ORFNames=CR201_G0031946 {ECO:0000313|EMBL:PNJ37466.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013246.1, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000013246.1, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ37466.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ37466.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000013246.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BTG family. {ECO:0000256|ARBA:ARBA00007989}.
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DR EMBL; NDHI03003480; PNJ37466.1; -; Genomic_DNA.
DR RefSeq; XP_009232674.1; XM_009234399.1.
DR STRING; 9601.ENSPPYP00000013246; -.
DR Ensembl; ENSPPYT00000013785.2; ENSPPYP00000013246.1; ENSPPYG00000011869.2.
DR GeneID; 100171740; -.
DR CTD; 10766; -.
DR eggNOG; KOG4006; Eukaryota.
DR GeneTree; ENSGT00940000154208; -.
DR HOGENOM; CLU_034687_0_0_1; -.
DR OMA; PGPLYFD; -.
DR OrthoDB; 11568at2759; -.
DR TreeFam; TF105274; -.
DR Proteomes; UP000001595; Chromosome 22.
DR Gene3D; 3.90.640.90; Anti-proliferative protein, N-terminal domain; 1.
DR InterPro; IPR002087; Anti_prolifrtn.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR036054; BTG-like_sf.
DR InterPro; IPR015676; Tob1/2.
DR PANTHER; PTHR17537:SF3; PROTEIN TOB2; 1.
DR PANTHER; PTHR17537; TRANSDUCER OF ERBB2 TOB; 1.
DR Pfam; PF07742; BTG; 1.
DR Pfam; PF07145; PAM2; 2.
DR PRINTS; PR00310; ANTIPRLFBTG1.
DR SMART; SM00099; btg1; 1.
DR SUPFAM; SSF160696; BTG domain-like; 1.
DR PROSITE; PS00960; BTG_1; 1.
DR PROSITE; PS01203; BTG_2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 40..60
FT /note="Anti-proliferative protein"
FT /evidence="ECO:0000259|PROSITE:PS00960"
FT DOMAIN 86..105
FT /note="Anti-proliferative protein"
FT /evidence="ECO:0000259|PROSITE:PS01203"
FT REGION 144..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 36601 MW; ADA1CD8939641BD5 CRC64;
MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLKKKY EGHWYPEKPL KGSGFRCVHI
GEMVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS YQIGEKGAVK VLYLDDSEGC
GAPELDKEIK SSFNPDAQVF VPIGSQDSSL SNSPSPSFGQ SPSPTFIPRS AQPITFTTAS
FAATKFGSTK MKKGGGAASG GGVASSGAGG QQPPQQPRMA RSPTNSLLKH KSLSLSMHSL
NFITANPAPQ SQLSPNAKEF VYNGGGSPSL FFDAADGQGS GTPGPFGGSG AGTCNSSSFD
MAQVFGGGAN SLFLEKTPFV EGLSYNLNTM QYPSQPFQPV VLAN
//
