ID H2P4R1_PONAB Unreviewed; 466 AA.
AC H2P4R1; A0A2J8TW73;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Nucleoporin 50 {ECO:0000313|Ensembl:ENSPPYP00000013314.3};
GN Name=NUP50 {ECO:0000313|Ensembl:ENSPPYP00000013314.3};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000013314.3, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000013314.3, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000013314.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
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DR AlphaFoldDB; H2P4R1; -.
DR STRING; 9601.ENSPPYP00000013314; -.
DR Ensembl; ENSPPYT00000013853.3; ENSPPYP00000013314.3; ENSPPYG00000011928.3.
DR eggNOG; KOG2724; Eukaryota.
DR GeneTree; ENSGT00440000035348; -.
DR HOGENOM; CLU_032593_0_0_1; -.
DR InParanoid; H2P4R1; -.
DR OMA; GIPCQRM; -.
DR OrthoDB; 4273059at2759; -.
DR TreeFam; TF106504; -.
DR Proteomes; UP000001595; Chromosome 22.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046907; P:intracellular transport; IEA:InterPro.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd13170; RanBD_NUP50; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR015007; NUP2/50/61.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR PANTHER; PTHR23138:SF141; NUCLEAR PORE COMPLEX PROTEIN NUP50; 1.
DR PANTHER; PTHR23138; RAN BINDING PROTEIN; 1.
DR Pfam; PF08911; NUP50; 1.
DR Pfam; PF00638; Ran_BP1; 1.
DR SMART; SM00160; RanBD; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50196; RANBD1; 1.
PE 4: Predicted;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00023132};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022816}.
FT DOMAIN 318..466
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 50059 MW; 9BC2A9C54169ED7D CRC64;
MAKRNAEKEL TDRNWDQEDE AEEVGTFSLA SEEVLKNRAI KKAKRRNVGF ESDSGGAFKG
FKGLVVPSGG GRFPGFGSGA GGKPLEGLSN GNNITSAPPF TSAKAAAEPK VAFGSLPANG
PTALVDKVSN PKTNGDSQQP SSSGLASSKA CVGSAYHKQL AALNCSVRDW IVKHVNTNPL
CDLTPIFKDY EKYLANIEQQ HGNSGRNSES EPNKVAAETQ SPSLFGSTKL QQESTFLFHG
NKTEDTPDKK VEVASEKKTD PSSLGATSAS FNFGKKVDSS VLGSLSSVPL TGFSFSPGNS
SVFGKDITQS KPVSSPFPTK PLEGQAEGYS GECKDEEENE EPPKVVVTEV KEEDAFYSKK
CKLFYKKDNE FKEKGIGTLH LKPTANQKTQ LLVRADTNLG NILLNVLIPP NMPCTRTGKN
NVLIVCVPNP PIDEKNATMP VTMLIRVKTS EDADELHKIL LEKKDA
//
