ID H2P6R6_PONAB Unreviewed; 745 AA.
AC H2P6R6; A0A2J8VMN0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Dynein regulatory complex protein 1 {ECO:0000256|ARBA:ARBA00013815};
DE AltName: Full=Coiled-coil domain-containing protein 164 {ECO:0000256|ARBA:ARBA00031554};
GN Name=DRC1 {ECO:0000313|Ensembl:ENSPPYP00000014046.2};
GN ORFNames=CR201_G0017729 {ECO:0000313|EMBL:PNJ58788.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000014046.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000014046.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PNJ58788.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Susie {ECO:0000313|EMBL:PNJ58788.1};
RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT "High-resolution comparative analysis of great ape genomes.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000014046.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000256|ARBA:ARBA00004611}.
CC -!- SIMILARITY: Belongs to the DRC1 family.
CC {ECO:0000256|ARBA:ARBA00009688}.
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DR EMBL; NDHI03003415; PNJ58788.1; -; Genomic_DNA.
DR STRING; 9601.ENSPPYP00000014046; -.
DR Ensembl; ENSPPYT00000014614.2; ENSPPYP00000014046.2; ENSPPYG00000012578.2.
DR eggNOG; ENOG502QQ2B; Eukaryota.
DR GeneTree; ENSGT00940000153804; -.
DR HOGENOM; CLU_012489_1_0_1; -.
DR OMA; MPQELHN; -.
DR OrthoDB; 5476746at2759; -.
DR TreeFam; TF324985; -.
DR Proteomes; UP000001595; Chromosome 2A.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IEA:Ensembl.
DR GO; GO:0060285; P:cilium-dependent cell motility; IEA:Ensembl.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR InterPro; IPR039505; DRC1/2_N.
DR InterPro; IPR039750; DRC1/DRC2.
DR InterPro; IPR029440; DRC1_C.
DR PANTHER; PTHR21625:SF1; DYNEIN REGULATORY COMPLEX PROTEIN 1; 1.
DR PANTHER; PTHR21625; NYD-SP28 PROTEIN; 1.
DR Pfam; PF14772; NYD-SP28; 1.
DR Pfam; PF14775; NYD-SP28_assoc; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 100..200
FT /note="Dynein regulatory complex protein 1/2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14772"
FT DOMAIN 665..724
FT /note="Dynein regulatory complex protein 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14775"
FT REGION 579..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 103..140
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 168..210
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 281..308
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 334..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 699..729
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 600..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 87711 MW; 719A64E0E2602B68 CRC64;
MNPPGSLEAL DPNVDEHLST QILAPSVHSD NSQERIQARR LRIAARLEAR RREALGEYLD
GKKESEEDQS KSYKQKEESR LKLAKLLLCG TELVTNIQVA IDIREIHRRV EEEEIKRQRI
EKLENEVKTS QDKFDEITSK WEEGKQKRIP QELWEMLNTQ QLHCAGLLED KNKLISELQQ
ELKTKDDQYV KDLKKQSDDI CLLLERMEEQ VKNVMKTFRE ELYNIEKAFE VERQELLASN
KKKWEQALQA HNAKELEYLI NRMKKVEDYE KQLNKQRIWD CEEYNMIKIK LEQDVQILEQ
QLQQRKAIYQ LNQEKLEYNL QVLKKRDEES TVIKSQQKRK INRLHDILNN LRSKYAKQIK
QFQEENQSLT SDYKRLVMQF KELQKAMRHF AVIDDEKFRE IWLMNEEEAK DLIARAFDVD
RIIHTHHLGL PWAAPDFWFL NNVGPISRQP QKSATQIVEE MLMRTEEEEA EEATSEPESY
LDLPKQISEK TTKRILMLLC DESGFLIESK LLSLLLPLEQ NECYLLRLDA IFSALGIESE
DDLYKLVNFF LKYRAHRLSS SLQIKPCSQV SMEKVSMEKA SMEETSMGSE LELAEQTEME
GEKEESLVEG KKEEEEKTPP SPWVIHPNDV LKILEAFVMG LKKPRDSWAP LRVQKNVRDN
SKDSEYWQAL TTVIPSSKQN LWDALYTALE KYHLVLTQRA KLLLENSSLE QQNTELQALL
QQYLNSKINS ELQVPPTQVL RVPTK
//
