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Database: UniProt
Entry: H2P832_PONAB
LinkDB: H2P832_PONAB
Original site: H2P832_PONAB 
ID   H2P832_PONAB            Unreviewed;      1012 AA.
AC   H2P832; A0A2J8WW78;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   24-JAN-2024, entry version 77.
DE   SubName: Full=ITGAV isoform 2 {ECO:0000313|EMBL:PNJ74021.1};
DE   SubName: Full=Integrin subunit alpha V {ECO:0000313|Ensembl:ENSPPYP00000014531.3};
GN   Name=ITGAV {ECO:0000313|Ensembl:ENSPPYP00000014531.3};
GN   ORFNames=CR201_G0007398 {ECO:0000313|EMBL:PNJ74021.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000014531.3, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000014531.3, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PNJ74021.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ74021.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA   Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA   Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA   Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA   Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPPYP00000014531.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   EMBL; NDHI03003377; PNJ74021.1; -; Genomic_DNA.
DR   STRING; 9601.ENSPPYP00000014531; -.
DR   Ensembl; ENSPPYT00000015120.3; ENSPPYP00000014531.3; ENSPPYG00000013007.3.
DR   eggNOG; KOG3637; Eukaryota.
DR   GeneTree; ENSGT00940000158361; -.
DR   HOGENOM; CLU_004111_4_0_1; -.
DR   TreeFam; TF105391; -.
DR   Proteomes; UP000001595; Chromosome 2B.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF4; INTEGRIN ALPHA-V; 1.
DR   Pfam; PF01839; FG-GAP; 3.
DR   Pfam; PF08441; Integrin_A_Ig_1; 1.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF20806; Integrin_A_Ig_3; 1.
DR   Pfam; PF00357; Integrin_alpha; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   PROSITE; PS51470; FG_GAP; 6.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           31..1012
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5040523941"
FT   TRANSMEM        958..980
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          32..98
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          109..170
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          201..255
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          256..321
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          322..379
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          383..446
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          431..589
FT                   /note="Integrin alpha first immunoglubulin-like"
FT                   /evidence="ECO:0000259|Pfam:PF08441"
FT   DOMAIN          590..728
FT                   /note="Integrin alpha second immunoglobulin-like"
FT                   /evidence="ECO:0000259|Pfam:PF20805"
FT   DOMAIN          736..947
FT                   /note="Integrin alpha third immunoglobulin-like"
FT                   /evidence="ECO:0000259|Pfam:PF20806"
FT   REGION          991..1012
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1012 AA;  112254 MW;  D9114204B32B835A CRC64;
     MASPPRRRLR LGPRVLPLLL SGLLLPLCRA FNLDVDSPAE YSGPEGSYFG FAVDFFVPSA
     SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSTRRCQPI EFDATGNRDY AKDDPLEFKS
     HQWFGASVRS KQDKILACAP LYHWRTEMKQ EREPVGTCFL QDGTKTVEYA PCRSRQLISD
     QVAEIVSKYD PNVYSIKYNN QLATRTAQAI FDDSYLGYSV AVGDFNGDGI DDFVSGVPRA
     ARTLGMVYIY DGKNMSSLYN FTGEQMAAYF GFSVAATDIN GDDYADVFIG APLFMDRGSD
     GKLQEVGQVS VSLQRASGDF QTTKLNGFEV FARFGSAIAP LGDLDQDGFN DIAIAAPYGG
     EDKKGIVYIF NGRSTGLNAV PSQILEGQWA ARSMPPSFGY SMKGATDIDK NGYPDLIVGA
     FGVDRAILYR ARPVITVNAG LEVYPSILNQ DNKTCSLPGT ALKVSCFNVR FCLKADGKGV
     LPRKLNFQVE LLLDKLKQKG AIRRALFLYS RSPSHSKNMT ISRGGLMQCE ELIAYLRDES
     EFRDKLTPIT IFMEYRLDYR TAADTTGLQP ILNQFTPANI SRQAHILLDC GEDNVCKPKL
     EVSVDSDQKK IYIGDDNPLT LIVKAQNQGE GAYEAELIVS IPLQADFIGV VRNNEALARL
     SCAFKTENQT RQVVCDLGNP MKAGTQLLAG LRFSVHQQSE MDTSVKFDLQ IQSSNLFDKV
     SPVVSHKVDL AVLAAVEIRG VSSPDHIFLP IPNWEHKENP ETEEDVGPVV QHIYELRNNG
     PSSFSKAMLH LQWPYKYNNN TLLYILHYDI DGPMNCTSDM EINPLRIKIS SLQTTEKNDT
     VAGQGERDHL ITKRDLALSE GDIHTLGCGV AQCLKIVCQV GRLDRGKSAI LYVKSLLWTE
     TFMNKENQNH SYSLKSSASF NVIEFPYKNL PIEDITNSTL VTTNVTWGIQ PAPMPVPVWV
     IILAVLAGLL LLAVLVFVMY RMGFFKRVRP PQEEQEREQL QPHENGEGNS ET
//
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