ID H2P8M6_PONAB Unreviewed; 238 AA.
AC H2P8M6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=FEV transcription factor, ETS family member {ECO:0000313|Ensembl:ENSPPYP00000014738.2};
GN Name=FEV {ECO:0000313|Ensembl:ENSPPYP00000014738.2};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000014738.2, ECO:0000313|Proteomes:UP000001595};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000014738.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPPYP00000014738.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR AlphaFoldDB; H2P8M6; -.
DR Ensembl; ENSPPYT00000015335.2; ENSPPYP00000014738.2; ENSPPYG00000013189.2.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000161562; -.
DR HOGENOM; CLU_045216_4_0_1; -.
DR InParanoid; H2P8M6; -.
DR OMA; TNMSCIA; -.
DR TreeFam; TF316214; -.
DR Proteomes; UP000001595; Chromosome 2B.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0042711; P:maternal behavior; IEA:Ensembl.
DR GO; GO:0048665; P:neuron fate specification; IEA:Ensembl.
DR GO; GO:0042551; P:neuron maturation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF203; PROTEIN FEV; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595}.
FT DOMAIN 47..127
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
SQ SEQUENCE 238 AA; 25061 MW; FFC326BC2067CC03 CRC64;
MRQSGASQPL LINMYLPDPV GDGLFKEGKN PSWGPLSPAV QKGSGQIQLW QFLLELLADR
ANAGCIAWEG GHGEFKLTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMSKVHGK
RYAYRFDFQG LAQACQPPPA HAHAAAAAAA AAAAAQDGAL YKLPAGLSPL PFPGLSKLNL
MAASAGVAPA GFSYWPGPGP AATAAAATAA LYPSPSLQPP PGPFGAVAAA SHLGGHYH
//
