ID   H2PAC8_PONAB            Unreviewed;       276 AA.
AC   H2PAC8; A0A2J8TEF7; A0A2J8TEI7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=SYNPR isoform 4 {ECO:0000313|EMBL:PNJ31411.1};
DE   SubName: Full=Synaptoporin {ECO:0000313|Ensembl:ENSPPYP00000015376.3};
GN   Name=SYNPR {ECO:0000313|Ensembl:ENSPPYP00000015376.3};
GN   ORFNames=CR201_G0035562 {ECO:0000313|EMBL:PNJ31411.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000015376.3, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000015376.3, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PNJ31411.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ31411.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M.,
RA   Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J.,
RA   Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M.,
RA   Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B.,
RA   Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPPYP00000015376.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the synaptophysin/synaptobrevin family.
CC       {ECO:0000256|ARBA:ARBA00006476}.
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DR   EMBL; NDHI03003502; PNJ31411.1; -; Genomic_DNA.
DR   RefSeq; XP_009237106.1; XM_009238831.1.
DR   STRING; 9601.ENSPPYP00000015376; -.
DR   Ensembl; ENSPPYT00000015989.3; ENSPPYP00000015376.3; ENSPPYG00000013748.3.
DR   eggNOG; ENOG502QT4W; Eukaryota.
DR   GeneTree; ENSGT01030000234637; -.
DR   HOGENOM; CLU_064642_0_1_1; -.
DR   OrthoDB; 2881347at2759; -.
DR   TreeFam; TF315804; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:InterPro.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR001285; Synaptophysin/porin.
DR   PANTHER; PTHR10306; SYNAPTOPHYSIN; 1.
DR   PANTHER; PTHR10306:SF16; SYNAPTOPORIN; 1.
DR   Pfam; PF01284; MARVEL; 1.
DR   PRINTS; PR00220; SYNAPTOPHYSN.
DR   PROSITE; PS51225; MARVEL; 1.
DR   PROSITE; PS00604; SYNAPTOP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW   ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        92..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          6..213
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000259|PROSITE:PS51225"
FT   REGION          232..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   276 AA;  30485 MW;  90F91B6965381ADF CRC64;
     MCMVIFAPHN EECKSHFHLL FAIFAFATCG GYSGGLRLSV DCVNKTESNL SIDIAFAYPF
     RLHQVTFEVP TCEGKERQKL ALIGDSSSSA EFFVTVAVFA FLYSLAATVV YIFFQNKYRE
     NNRGPLIDFI VTVVFSFLWL VGSSAWAKGL SDVKVATDPK EVLLLMSACK QPSNKCMAIH
     SPVMSSLNTS VVFGFLNFIL WAGNIWFVFK ETGWHSSGQR YLSDPMEKHS SSYNQGGYNQ
     DSYGSSGGYS QQASLGPSSD EFGQQPTGPT SFTNQI
//