ID   H2PAU5_PONAB            Unreviewed;       238 AA.
AC   H2PAU5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Protein shisa-5 {ECO:0000256|ARBA:ARBA00040441};
DE   AltName: Full=Scotin {ECO:0000256|ARBA:ARBA00041983};
GN   Name=SHISA5 {ECO:0000313|Ensembl:ENSPPYP00000015550.2};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000015550.2, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000015550.2, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000015550.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC       a role in p53/TP53-dependent apoptosis.
CC       {ECO:0000256|ARBA:ARBA00037507}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the shisa family.
CC       {ECO:0000256|ARBA:ARBA00038108}.
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DR   AlphaFoldDB; H2PAU5; -.
DR   Ensembl; ENSPPYT00000016169.2; ENSPPYP00000015550.2; ENSPPYG00000013902.3.
DR   GeneTree; ENSGT00390000008296; -.
DR   HOGENOM; CLU_093192_1_0_1; -.
DR   InParanoid; H2PAU5; -.
DR   OMA; MCRKPQP; -.
DR   TreeFam; TF332572; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31395:SF14; PROTEIN SHISA-5; 1.
DR   PANTHER; PTHR31395; SHISA; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..238
FT                   /note="Protein shisa-5"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035314289"
FT   TRANSMEM        108..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   238 AA;  25449 MW;  B9B7D0FBBADC6075 CRC64;
     MTAPVPAPRI LLLLLLLLPP PPGARCEVCM ASRGLSLFPE SCPDFCCGTC HDQYCCSDVL
     KKFVWTEKRC AVPEASVPAS VEPVEQLGSA LRFRPGYNDP MSGFGATLAV GLTIFVLSVV
     TIIICFTCSC CCLYKTCRRP RPVVTTTTST TVVHAPYPQP PSVPPSYPGP SYQGYHTMPP
     QPGMPAAPYP MQYPPPYPAQ PMGPPAYHET LAGGAAAPYP ASQPPYNPAY MDAPKAAL
//