GenomeNet

Database: UniProt
Entry: H2PC55_PONAB
LinkDB: H2PC55_PONAB
Original site: H2PC55_PONAB 
ID   H2PC55_PONAB            Unreviewed;       471 AA.
AC   H2PC55; A0A2J8WH59;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   31-JUL-2019, entry version 49.
DE   SubName: Full=HTR3E isoform 3 {ECO:0000313|EMBL:PNJ69112.1};
GN   Name=HTR3E {ECO:0000313|Ensembl:ENSPPYP00000016039};
GN   ORFNames=CR201_G0010594 {ECO:0000313|EMBL:PNJ69112.1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000016039, ECO:0000313|Proteomes:UP000001595};
RN   [1] {ECO:0000313|Ensembl:ENSPPYP00000016039, ECO:0000313|Proteomes:UP000001595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPPYP00000016039}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:PNJ69112.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Susie {ECO:0000313|EMBL:PNJ69112.1};
RA   Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
RA   Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
RA   Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
RA   Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
RA   Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
RA   Haussler D., Eichler E.;
RT   "High-resolution comparative analysis of great ape genomes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; ABGA01362933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01362934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01362935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; NDHI03003390; PNJ69112.1; -; Genomic_DNA.
DR   RefSeq; XP_009237874.1; XM_009239599.1.
DR   STRING; 9601.ENSPPYP00000016039; -.
DR   Ensembl; ENSPPYT00000016683; ENSPPYP00000016039; ENSPPYG00000014342.
DR   GeneID; 100444924; -.
DR   CTD; 285242; -.
DR   eggNOG; KOG3645; Eukaryota.
DR   eggNOG; ENOG410XQGR; LUCA.
DR   GeneTree; ENSGT00940000163899; -.
DR   InParanoid; H2PC55; -.
DR   OMA; EFMDVDK; -.
DR   OrthoDB; 123230at2759; -.
DR   TreeFam; TF315605; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022850; F:serotonin-gated cation-selective channel activity; IEA:Ensembl.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001595};
KW   Ion channel {ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000687}.
FT   TRANSMEM    264    288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    294    311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    449    469       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       67    262       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      269    419       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      398    429       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   471 AA;  52724 MW;  EDCEF24841F926B2 CRC64;
     MSAFILSRAT PGPALGPLSY REHRVALLHL THLMSTTGRG VTFTINCSGF GQHGADPTAL
     NSVFNRKPFR PVTNISVPTR VNISFTMSAI LDVNEQLHLL SSFLWLEMVW DNPFISWNPE
     ECEGITKMSM AAKNLWLPDI FIVELTNVNK TPKDLTAYVS NEGRIRYKKP MKVDSICNLD
     IFYFPFDQQN CTLTFSSFLY TVEDMLLGME KEVWEITDAS QNILQTHGEW ELLGINKATA
     KLSRGGNLYD QIVFYVAIRR RPSLYVINLL VPSGFLVAID ALSCHLPVKS GNRVPFKITL
     LLGYNVFLLT MSDLLPTCGT PLIGVYFALC LSLMVVSLLE TIFITHLLHV ATTQPPPMPW
     WLHSLLLHCT SPGRCCPTAP QKGNKGLGLT PTHLPGVKEP EVSAGQMPGP GEAELTEGSE
     RTRAQREHEA QKQHSVELWV QFSHTMDALL FRLYLLFMAS SIITVICLWN T
//
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